3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione

Base Information

Chemical Name:3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione
CAS No.:1272379-78-8
Molecular Formula:C₃₆H₃₆Cl₂N₆O₃S
Molecular Weight:703.692
Hs Code.:

3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione

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Chemical Property of 3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione

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Technology Process of 3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione

There total 5 articles about 3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 65950-49-4
2-[2-(2,6-dichlorophenyl)aminophenyl]acetyl chloride

: 1272379-72-2
5-phenyl-12-(pyrrolidin-1-yl)-3-sulfanylmethyl-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

: 1272379-78-8
3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione

Guidance literature:: With triethylamine; In benzene; for 4h; Reflux;
DOI:10.1007/s00044-010-9545-5

Reference yield:

: 1272379-56-2
3-chloromethyl-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydropyrimido[4',5':4,5]pyrimido[1,6-a]azepine-1,6-dione

: 1272379-78-8
3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1: thiourea / ethanol / 3 h / Reflux

2: triethylamine / benzene / 4 h / Reflux

With triethylamine; thiourea; In ethanol; benzene;
DOI:10.1007/s00044-010-9545-5

Reference yield:

: C₁₆H₁₇ClN₄O

: 1272379-78-8
3-[[2-(2,6-dichlorophenylamino)phenyl]acetylsulfanylmethyl]-5-phenyl-12-(pyrrolidin-1-yl)-1,2,5,6,8,9,10,11,12,12a-decahydroprimido[4',5':4,5]pyrimido[1,6-a]azepine1,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol

2: sodium tetrahydroborate / ethanol

3: triethylamine / benzene / 2 h / 70 °C

4: thiourea / ethanol / 3 h / Reflux

5: triethylamine / benzene / 4 h / Reflux

With sodium tetrahydroborate; triethylamine; thiourea; In ethanol; benzene;
DOI:10.1007/s00044-010-9545-5