C₁₄H₉FN₂OS

Base Information

• Chemical Name: C₁₄H₉FN₂OS
• CAS No.: 1446715-66-7
• Molecular Formula: C₁₄H₉FN₂OS
• Molecular Weight: 272.303
• Mol file: 1446715-66-7.mol

Synonyms:

Chemical Property of C₁₄H₉FN₂OS

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₉FN₂OS

There total 3 articles about C₁₄H₉FN₂OS which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 2,4-dioxopiperidine-1-carboxylate (845267-78-9) → C14H9FN2OS (1446715-66-7)

Guidance literature:

Multi-step reaction with 4 steps

1: N-Bromosuccinimide / tetrahydrofuran / 1 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 150 °C

3: copper(ll) bromide; isopentyl nitrite / tetrahydrofuran / 1 h / 0 - 20 °C

4: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 140 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; potassium carbonate; triethylamine; copper(ll) bromide; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide; 4: |Sonogashira Cross-Coupling;

DOI:10.1016/j.bmcl.2013.05.070

Reference yield:

tert-butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate (1312412-87-5) → C14H9FN2OS (1446715-66-7)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 150 °C

2: copper(ll) bromide; isopentyl nitrite / tetrahydrofuran / 1 h / 0 - 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.25 h / 140 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; copper(ll) bromide; isopentyl nitrite; In tetrahydrofuran; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;

DOI:10.1016/j.bmcl.2013.05.070

Reference yield:

1-ethynyl-4-fluorobenzene (766-98-3) + 2-bromo-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one (1035219-96-5) → C14H9FN2OS (1446715-66-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; at 140 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.bmcl.2013.05.070

upstream raw materials:

1-ethynyl-4-fluorobenzene

2-bromo-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

tert-butyl 2,4-dioxopiperidine-1-carboxylate

tert-butyl 3-bromo-2,4-dioxopiperidine-1-carboxylate