(R)-thiabutazide

Base Information

• Chemical Name: (R)-thiabutazide
• CAS No.: 96783-07-2
• Molecular Formula: C₁₁H₁₆ClN₃O₄S₂
• Molecular Weight: 353.851
• Mol file: 96783-07-2.mol

Synonyms:

Chemical Property of (R)-thiabutazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-thiabutazide

There total 3 articles about (R)-thiabutazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

chloraminophenamide (121-30-2) + isovaleraldehyde (590-86-3) → (R)-thiabutazide (96783-07-2)

Guidance literature:

With C₆₄H₇₃O₄P; In dichloromethane; at 20 ℃; for 168h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/ja8071034

Reference yield:

butizide (2043-38-1,96782-77-3) → (R)-thiabutazide (96783-07-2) + thiabutazide

Guidance literature:

With isopropylamine; trifluoroacetic acid; In methanol; isopropyl alcohol; at 35 ℃; under 103432 Torr; Reagent/catalyst; Solvent; Resolution of racemate; Supercritical conditions;

DOI:10.1002/chir.22701

Reference yield:

chloraminophenamide (121-30-2) + isovaleraldehyde (590-86-3) → (R)-thiabutazide (96783-07-2) + thiabutazide

Guidance literature:

With pentakis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl)cyclopenta-1,3-diene-1,2,3,4,5-pentacarboxylate; In dichloromethane; at 25 ℃; for 72h; Temperature; Solvent; Overall yield = 61 %; Overall yield = 43 mg; enantioselective reaction; Molecular sieve; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201701561

upstream raw materials:

chloraminophenamide

isovaleraldehyde

butizide