121-30-2Relevant articles and documents
Adsorption of benzothiadiazines by carbon black from aqueous solution, and related phenomena
Ueda,Nambu,Nagai
, p. 3426 - 3430 (1980)
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Stability-indicating assay for hydrochlorothiazide
Daniels,Vanderwielen
, p. 211 - 215 (1981)
A stability-indicating method for determining hydrochlorothiazide in tablet formulations and in the bulk form is described. Hydrochlorothiazide is dissolved or extracted using methanol. An aliquot of the solution, containing sulfadiazine as an internal standard, is chromatographed on a 10-μm C18 column with an aqueous mobile phase containing 5% methanol as the modifier. The pH is adjusted to about 4.5 with acetic acid. The method gave accurate results for nine lots (four different suppliers) of tablets and two bulk drug lots (two different suppliers). The assay has a relative standard deviation of about 1%. The method can also be used as a test for impurities in hydrochlorothiazide. The data in this study indicate that the test should give accurate results for impurities between 0.1 and 5%.
Accelerated Forced Degradation of Pharmaceuticals in Levitated Microdroplet Reactors
Li, Yangjie,Liu, Yong,Gao, Hong,Helmy, Roy,Wuelfing, W. Peter,Welch, Christopher J.,Cooks, R. Graham
, p. 7349 - 7353 (2018)
Forced degradation is a method of studying the stability of pharmaceuticals in order to design stable formulations and predict drug product shelf life. Traditional methods of reaction and analysis usually take multiple days, and include LC-UV and LC-MS product analysis. In this study, the reaction/analysis sequence was accelerated to be completed within minutes using Leidenfrost droplets as reactors (acceleration factor: 23–188) and nanoelectrospray ionization MS analysis. The Leidenfrost droplets underwent the same reactions as seen in traditional bulk solution experiments for three chemical degradations studied. This combined method of accelerated reaction and analysis has the potential to be extended to forced degradation of other pharmaceuticals and to drug formulations. Control of reaction rate and yield is achieved by manipulating droplet size, levitation time and whether or not make-up solvent is added. Evidence is provided that interfacial effects contribute to rate acceleration.
Weinstok,R.,Kratzl,K.
, p. 1586 - 1591 (1965)
Epimerization and racemization of some chiral drugs in the presence of human serum albumin
Aso,Yoshioka,Takeda
, p. 180 - 184 (2007/10/02)
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