2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester

Base Information

Chemical Name:2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester
CAS No.:873553-09-4
Molecular Formula:C₄₀H₃₆N₂O₁₀
Molecular Weight:704.733
Hs Code.:

2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4<i>H</i>-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester

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Chemical Property of 2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester

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Technology Process of 2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester

There total 4 articles about 2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 853294-39-0
3-methoxy-4-oxo-2-phenyl-4H-chromene-8-carbaldehyde

: 88150-75-8
ethyl 4-[2-(phthalimido)ethoxy]acetoacetate

: 14205-41-5
3-Aminocrotonsaeure-allylester

: 873553-09-4
2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester

Guidance literature:: In isopropyl alcohol; for 20h; Heating;
DOI:10.1016/j.bmc.2005.03.007

Reference yield:

: 87165-68-2
3-methoxy-8-methyl-2-phenylchromen-4-one

: 873553-09-4
2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄ / 4 h / Heating

2: 80 percent / hexamethylenetetramine; acetic acid / 5 h / Heating

3: 40 percent / propan-2-ol / 20 h / Heating

With N-Bromosuccinimide; hexamethylenetetramine; acetic acid; dibenzoyl peroxide; In tetrachloromethane; isopropyl alcohol; 3: Hantzsch dihydropyridine synthesis;
DOI:10.1016/j.bmc.2005.03.007

Reference yield:

: 87165-69-3
8-bromomethyl-3-methoxy-2-phenylchromen-4-one

: 873553-09-4
2-[2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-ethoxymethyl]-4-(3-methoxy-4-oxo-2-phenyl-4H-chromen-8-yl)-6-methyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 5-allyl ester 3-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / hexamethylenetetramine; acetic acid / 5 h / Heating

2: 40 percent / propan-2-ol / 20 h / Heating

With hexamethylenetetramine; acetic acid; In isopropyl alcohol; 2: Hantzsch dihydropyridine synthesis;
DOI:10.1016/j.bmc.2005.03.007