1H-IMIDAZOLE-5-CARBOHYDRAZIDE

Base Information

• Chemical Name: 1H-IMIDAZOLE-5-CARBOHYDRAZIDE
• CAS No.: 18329-78-7
• Molecular Formula: C4H6 N4 O
• Molecular Weight: 126.118
• Mol file: 18329-78-7.mol

Synonyms:1H-Imidazole-4-carboxylicacid, hydrazide (9CI); Imidazole-4(or 5)-carboxylic acid, hydrazide (7CI);Imidazole-4-carboxylic acid, hydrazide (8CI); (4-Imidazolylcarbonyl)hydrazine;Idv 124; NSC 14584

Chemical Property of 1H-IMIDAZOLE-5-CARBOHYDRAZIDE

Chemical Property:

• PSA: 83.80000
• Density: 1.425g/cm³
• LogP: 0.10440

Purity/Quality:

98%min ^*data from raw suppliers

1H-imidazole-4-carbohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-IMIDAZOLE-5-CARBOHYDRAZIDE

There total 5 articles about 1H-IMIDAZOLE-5-CARBOHYDRAZIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Methyl imidazole-4-carboxylate (17325-26-7) → 1H-imidazole-4-carboxylic acid hydrazide (18329-78-7)

Guidance literature:

With hydrazine hydrate; Heating;

DOI:10.1016/S0040-4020(97)00149-X

Reference yield: 46.3%

1H-imidazole-5-carboxylic acid ethyl ester (23785-21-9) → imidazole, 5-hydrazinocarbonyl- (18329-78-7)

Guidance literature:

With hydrazine hydrate; In toluene; for 3h; Heating;

DOI:10.1016/j.bmc.2020.115891

Reference yield: 39.0%

ethyl 1H-imidazole-4-carboxylate (23785-21-9) → 1H-imidazole-4-carboxylic acid hydrazide (18329-78-7)

Guidance literature:

With hydrazine hydrate; In ethanol; at 80 ℃; for 4h;

DOI:10.1016/j.tca.2014.01.022

upstream raw materials:

1H-imidazole-5-carboxylic acid ethyl ester

Methyl imidazole-4-carboxylate

ethyl 1H-imidazole-4-carboxylate

Refernces

• 1、 Dai, Baozhu,Ma, Xingxing,Tang, Yadong,Xu, Le,Guo, Su,Chen, Xinyan,Lu, Shitong,Wang, Guangjie,Liu, Yajing. "Design, synthesis, and biological activity of novel semicarbazones as potent Ryanodine receptor1 inhibitors of Alzheimer's disease". . . Retrieved 2020/12/09.
• 2、 Zhao, He,Burke Jr., Terrence R.. "Pentafluorophenyl ester activation for the preparation of N,N'-diaroylhydrazines". . p. 4219 - 4230. Retrieved 2007/10/03.