23785-21-9Relevant articles and documents
NAPHTHO[2,1 -D]THIAZOLE DERIVATIVES, COMPOSITIONS THEREOF AND METHODS OF TREATING DISORDERS
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Paragraph 0143, (2021/05/29)
The present application relates to the compounds of formula (I) that inhibit CDK9, pharmaceutical compositions thereof and methods of making and using the same.
Efficient synthesis method of pharmaceutical intermediate 1H-imidazole-4-formic acid
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Paragraph 0022-0026; 0028-0032; 0034-0038; 0040-0044; 0046, (2018/12/14)
The invention discloses an efficient synthesis method of a pharmaceutical intermediate 1H-imidazole-4-formic acid. The efficient synthesis method specifically comprises the following steps: firstly, preparing a titanium dioxide/titanium niobate compound catalyst; then taking 2-thiol-4-imidazole ethyl formate as a raw material; preparing 1H-imidazole-4-ethyl formate under the action of a hydrogen peroxide solution and a compound catalyst; then enabling the 1H-imidazole-4-ethyl formate to react with alkali liquid to prepare a target product. The efficient synthesis method disclosed by the invention has a simple reaction process and raw materials are cheap and easy to obtain; the prepared target product is simple to separate and the yield reaches 90 percent or more.
Synthesis method of 4(5)-hydroxymethylimidazole
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Paragraph 0072; 0073, (2016/12/01)
The invention discloses a synthesis method of 4(5)-hydroxymethylimidazole. With 4,5-imidazoledicarboxylic acid as the raw material, decarboxylic reaction, esterification reaction and reduction reaction are conducted, manganese dioxide solid, ferric sulfate powder and a loaded Ni-Cu/SiO2 catalyst are added for catalytic reaction, reaction efficiency is improved, and reaction operation is simplified; meanwhile, the reaction process is improved, that is, the precipitation of 4(5)-imidazole carboxylic acid imidazole is promoted by adding sodium nitrate solid 5, the addition of concentrated sulfuric acid and a sodium hydroxide solution for neutralizing concentrated sulfuric acid is reduced by adding a catalyst, reaction consumption is reduced, reaction efficiency is improved, reaction operation is simplified, and high industrial popularization value is achieved.
