Technology Process of (+/-)-(E)-5-methyl-4-(3-((4-nitrophenyl)sulfonyl)ureido)hex-2-en-1-yl acetate
There total 5 articles about (+/-)-(E)-5-methyl-4-(3-((4-nitrophenyl)sulfonyl)ureido)hex-2-en-1-yl acetate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
triethylamine;
In
tetrahydrofuran;
at 20 ℃;
DOI:10.1021/ja405394v
- Guidance literature:
-
Multi-step reaction with 2 steps
1: phenanthridine; bis(trichloromethyl) carbonate / 1,2-dichloro-benzene / 100 °C
2: triethylamine / tetrahydrofuran / 20 °C
With
phenanthridine; bis(trichloromethyl) carbonate; triethylamine;
In
tetrahydrofuran; 1,2-dichloro-benzene;
DOI:10.1021/ja405394v
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran / 0.5 h / -78 - 20 °C
1.2: 0 °C
2.1: sodium azide; zinc(II) chloride; tetrabutylammomium bromide / tetrahydrofuran / 65 - 70 °C / Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere
4.1: triethylamine / tetrahydrofuran / 20 °C
With
1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; sodium azide; tetrabutylammomium bromide; triethylamine; trifluoroacetic acid; zinc(II) chloride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ja405394v
