2,4-methoxy-α,α-dimethylbenzenebutanol

Base Information

• Chemical Name: 2,4-methoxy-α,α-dimethylbenzenebutanol
• CAS No.: 156868-45-0
• Molecular Formula: C₁₄H₂₂O₃
• Molecular Weight: 238.327
• Mol file: 156868-45-0.mol

Synonyms:

Chemical Property of 2,4-methoxy-α,α-dimethylbenzenebutanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-methoxy-α,α-dimethylbenzenebutanol

There total 7 articles about 2,4-methoxy-α,α-dimethylbenzenebutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

methylmagnesium bromide (75-16-1) + 2,4-dimethoxybenzenebutanoic acid methyl ester (156868-43-8) → 2,4-methoxy-α,α-dimethylbenzenebutanol (156868-45-0)

Guidance literature:

In diethyl ether; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(01)87011-3

Reference yield:

3-(2',4'-dimethoxybenzoyl)propionic acid (14617-06-2) → 2,4-methoxy-α,α-dimethylbenzenebutanol (156868-45-0)

Guidance literature:

Multi-step reaction with 4 steps

1: (COCl)2 / CH₂Cl₂; dimethylformamide / Ambient temperature

2: triethylamine / CH₂Cl₂ / Ambient temperature

3: 24 percent / 37 percent HCl, water, H₂ / 10 percent Pd/C / methanol / 2585.7 Torr / Ambient temperature; Parr hydrogenator

4: 91 percent / diethyl ether / 24 h / Ambient temperature

With hydrogenchloride; oxalyl dichloride; water; hydrogen; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)87011-3

Reference yield:

1,3-Dimethoxybenzene (151-10-0) → 2,4-methoxy-α,α-dimethylbenzenebutanol (156868-45-0)

Guidance literature:

Multi-step reaction with 5 steps

1: AlCl₃ / 1,2-dichloro-ethane / 24 h / Ambient temperature

2: (COCl)2 / CH₂Cl₂; dimethylformamide / Ambient temperature

3: triethylamine / CH₂Cl₂ / Ambient temperature

4: 24 percent / 37 percent HCl, water, H₂ / 10 percent Pd/C / methanol / 2585.7 Torr / Ambient temperature; Parr hydrogenator

5: 91 percent / diethyl ether / 24 h / Ambient temperature

With hydrogenchloride; aluminium trichloride; oxalyl dichloride; water; hydrogen; triethylamine; palladium on activated charcoal; In methanol; diethyl ether; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)87011-3

upstream raw materials:

methylmagnesium bromide

2,4-dimethoxybenzenebutanoic acid methyl ester

3-(2',4'-dimethoxybenzoyl)propionic acid

4-(2,4-dimethoxy-phenyl)-4-oxo-butyric acid methyl ester