Technology Process of 2-isopropenyl-6-hydroxy-4-(2-phenylethyl)dihydrobenzofuran
There total 3 articles about 2-isopropenyl-6-hydroxy-4-(2-phenylethyl)dihydrobenzofuran which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) 1.6 M n-BuLi / 1) diethyl ether, 8 h, reflux, 2) diethyl ether, 1 H, 40 deg C
2: 69 percent / EtSNa / dimethylformamide / 3 h / 170 - 180 °C
3: 57.2 percent / EtSNa / hexamethylphosphoric acid triamide / 5 h / 170 - 180 °C
4: 1) 28percent NaOMe / 1) MeOH, 2) benzene, reflux
With
n-butyllithium; sodium methylate; sodium thioethylate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1016/0031-9422(91)84130-K
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 69 percent / EtSNa / dimethylformamide / 3 h / 170 - 180 °C
2: 57.2 percent / EtSNa / hexamethylphosphoric acid triamide / 5 h / 170 - 180 °C
3: 1) 28percent NaOMe / 1) MeOH, 2) benzene, reflux
With
sodium methylate; sodium thioethylate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide;
DOI:10.1016/0031-9422(91)84130-K
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 57.2 percent / EtSNa / hexamethylphosphoric acid triamide / 5 h / 170 - 180 °C
2: 1) 28percent NaOMe / 1) MeOH, 2) benzene, reflux
With
sodium methylate; sodium thioethylate;
In
N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/0031-9422(91)84130-K
