3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

Base Information

• Chemical Name: 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester
• CAS No.: 198011-26-6
• Molecular Formula: C₃₆H₄₃N₃O₇
• Molecular Weight: 629.753

Synonyms:

Chemical Property of 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

Chemical Property:

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Technology Process of 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

There total 4 articles about 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(6-Benzyloxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester → 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester (198011-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: H₂ / Pd/C

2: K₂CO₃

With hydrogen; potassium carbonate; palladium on activated charcoal;

DOI:10.1016/S0960-894X(97)10014-2

Reference yield:

4-cyanobenzyl bromide (17201-43-3) → 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester (198011-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃

With potassium carbonate;

DOI:10.1016/S0960-894X(97)10014-2

Reference yield:

3-(6-Hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester (198011-13-1) → 3-{6-[4-(tert-Butoxycarbonylamino-imino-methyl)-benzyloxy]-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl}-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester (198011-26-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃

With potassium carbonate;

DOI:10.1016/S0960-894X(97)10014-2

upstream raw materials:

di-tert-butyl dicarbonate

3-[6-(4-Cyano-benzyloxy)-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl]-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

4-cyanobenzyl bromide

3-(6-Hydroxy-1-oxo-3,4-dihydro-1H-isoquinolin-2-yl)-3-(4-methoxy-phenyl)-propionic acid tert-butyl ester

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