2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid

Base Information

• Chemical Name: 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid
• CAS No.: 1301168-11-5
• Molecular Formula: C₄H₆O₄*C₂₃H₂₁FN₄O₂
• Molecular Weight: 522.533
• Mol file: 1301168-11-5.mol

Synonyms:

Chemical Property of 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid

There total 5 articles about 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-hydroxymethyl-5-methoxypyridine (127978-70-5) → 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid (1301168-11-5)

Guidance literature:

Reference yield:

4-(3-(4-(benzyloxy)phenyl)-1-(2-fluoroethyl)-1H-pyrazol-4-yl)pyridine (1301167-63-4) → 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid (1301168-11-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 5%-palladium/activated carbon; hydrogen / ethanol / 80 °C / 760.05 Torr

2: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation

3: methanol

With di-tert-butyl-diazodicarboxylate; 5%-palladium/activated carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; methanol; ethanol;

DOI:10.1021/jm200536d

Reference yield:

4-[3-(4-benzyloxyphenyl)-1H-pyrazol-4-yl]pyridine (898563-86-5) → 2-[4-[1-(2-fluoroethyl)-4-(4-pyridinyl)-1H-pyrazol-3-yl]phenoxymethyl]-3-methoxypyridine succinic acid (1301168-11-5)

Guidance literature:

Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 0.08 h / 150 °C / Microwave irradiation

2: 5%-palladium/activated carbon; hydrogen / ethanol / 80 °C / 760.05 Torr

3: di-tert-butyl-diazodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.33 h / 120 °C / Microwave irradiation

4: methanol

With di-tert-butyl-diazodicarboxylate; 5%-palladium/activated carbon; hydrogen; caesium carbonate; triphenylphosphine; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm200536d

upstream raw materials:

4-(3-(4-(benzyloxy)phenyl)-1-(2-fluoroethyl)-1H-pyrazol-4-yl)pyridine

2-Hydroxymethyl-3-methoxy pyridine

4-[1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenol

succinic acid

Refernces

• 1、 Andrés, José-Ignacio,De Angelis, Meri,Alcázar, Jesús,Iturrino, Laura,Langlois, Xavier,Dedeurwaerdere, Stefanie,Lenaerts, Ilse,Vanhoof, Greet,Celen, Sofie,Bormans, Guy. "Synthesis, in vivo occupancy, and radiolabeling of potent phosphodiesterase subtype-10 inhibitors as candidates for positron emission tomography imaging". . p. 5820 - 5835. Retrieved 2011/10/09.