Technology Process of 6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid
There total 8 articles about 6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine;
In
N,N-dimethyl-formamide;
at 20 ℃;
for 2h;
DOI:10.1002/cmdc.201300115
- Guidance literature:
-
Multi-step reaction with 5 steps
1: iodine / dichloromethane / 4 h / 20 °C
2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3: sodium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C
4: trifluoroacetic acid / dichloromethane / 20 °C
5: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
2: |Sonogashira Cross-Coupling;
DOI:10.1002/cmdc.201300115
- Guidance literature:
-
Multi-step reaction with 6 steps
1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: iodine / dichloromethane / 4 h / 20 °C
3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
4: sodium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C
5: trifluoroacetic acid / dichloromethane / 20 °C
6: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;
DOI:10.1002/cmdc.201300115