6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

Base Information

Chemical Name:6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid
CAS No.:1404436-81-2
Molecular Formula:C₃₂H₃₇F₃N₂O₆
Molecular Weight:602.651
Hs Code.:

6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

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Chemical Property of 6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

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Technology Process of 6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

There total 8 articles about 6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1404436-78-7
3-(3-aminopropanoyl)-6-hydroxy-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

: 94133-41-2
(+)-menthyloxyacetic acid

: 1404436-81-2
6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1002/cmdc.201300115

Reference yield:

: 1404436-83-4
methyl 4-(dimethylamino)-2-hydroxy-5-((2-(trifluoromethyl)phenyl)ethynyl)benzoate

: 1404436-81-2
6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: iodine / dichloromethane / 4 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3: sodium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 20 °C

5: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1002/cmdc.201300115

Reference yield:

: 1143579-89-8
methyl 4-(dimethylamino)-2-hydroxy-5-iodobenzoate

: 1404436-81-2
6-hydroxy-3-(3-(2-(((1S,2R,5S)-2-isopropyl-5-methylcyclohexyl)oxy)acetamido)propanoyl)-1-methyl-2-(2-(trifluoromethyl)phenyl)-1H-indole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: iodine / dichloromethane / 4 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4: sodium hydroxide / tetrahydrofuran; methanol / 48 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 20 °C

6: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; iodine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 1: |Sonogashira Cross-Coupling / 3: |Sonogashira Cross-Coupling;
DOI:10.1002/cmdc.201300115