C₄₆H₆₂O₈

Base Information

Chemical Name:C₄₆H₆₂O₈
CAS No.:871912-75-3
Molecular Formula:C₄₆H₆₂O₈
Molecular Weight:742.993
Hs Code.:

C<sub>46</sub>H<sub>62</sub>O<sub>8</sub>

Synonyms:

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Chemical Property of C₄₆H₆₂O₈

Chemical Property:

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Technology Process of C₄₆H₆₂O₈

There total 15 articles about C₄₆H₆₂O₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871912-74-2
(2R,3S,4S,4aR,6S,8S,9S,9aS)-9-Benzyloxy-6-((2R,3S,5R,7R,8S)-7-benzyloxy-8-benzyloxymethyl-3-hydroxy-5-methyl-oxocan-2-ylmethyl)-2-[3-(tert-butyl-diphenyl-silanyloxy)-propyl]-3,4,8-trimethyl-hexahydro-1,5-dioxa-benzocyclohepten-7-one

: 871912-75-3
C₄₆H₆₂O₈

Guidance literature:: With triethylsilane; trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at 0 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2005.09.164

Reference yield:

: (2R,4aR,6S,7R,9S,10aS)-6-Hydroxymethyl-9-methyl-2-phenyl-octahydro-1,3,5-trioxa-benzocycloocten-7-ol

: 871912-75-3
C₄₆H₆₂O₈

Guidance literature:: Multi-step reaction with 13 steps

1.1: tBuOK; TBAI / tetrahydrofuran / 0.5 h / 23 °C

2.1: ethanedithiol; BF₃Et₂O / CH₂Cl₂ / 0.5 h / -20 °C

3.1: 93 percent / PPTS / benzene / 12 h / Heating

4.1: 85 percent / LiAlH₄; AlCl₃ / CH₂Cl₂; diethyl ether / 2 h / 23 °C

5.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -20 °C

6.1: NHMDS / tetrahydrofuran / 0.25 h / -20 °C

7.1: LDA / tetrahydrofuran / 0.25 h / -20 °C

7.2: 98 percent / tetrahydrofuran / 0.5 h / -78 °C

8.1: 69 percent / PTS / methanol / 0.5 h / 23 °C

9.1: 73 percent / TMSOTf; Et₃SiH / CH₂Cl₂ / 0.5 h / 0 °C

10.1: 87 percent / imidazole / dimethylformamide / 0.5 h / 23 °C

11.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.17 h / -78 °C

12.1: DDQ / CH₂Cl₂ / 0.17 h / 23 °C / pH 7

13.1: TMSOTf; Et₃SiH / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; triethylsilane; ethandithiol; lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.tetlet.2005.09.164

Reference yield:

: (2R,4aR,6S,7R,9S,10aS)-7-Benzyloxy-6-benzyloxymethyl-9-methyl-2-phenyl-octahydro-1,3,5-trioxa-benzocyclooctene

: 871912-75-3
C₄₆H₆₂O₈

Guidance literature:: Multi-step reaction with 12 steps

1.1: ethanedithiol; BF₃Et₂O / CH₂Cl₂ / 0.5 h / -20 °C

2.1: 93 percent / PPTS / benzene / 12 h / Heating

3.1: 85 percent / LiAlH₄; AlCl₃ / CH₂Cl₂; diethyl ether / 2 h / 23 °C

4.1: 2,6-lutidine / CH₂Cl₂ / 0.5 h / -20 °C

5.1: NHMDS / tetrahydrofuran / 0.25 h / -20 °C

6.1: LDA / tetrahydrofuran / 0.25 h / -20 °C

6.2: 98 percent / tetrahydrofuran / 0.5 h / -78 °C

7.1: 69 percent / PTS / methanol / 0.5 h / 23 °C

8.1: 73 percent / TMSOTf; Et₃SiH / CH₂Cl₂ / 0.5 h / 0 °C

9.1: 87 percent / imidazole / dimethylformamide / 0.5 h / 23 °C

10.1: (COCl)2; DMSO; Et₃N / CH₂Cl₂ / 0.17 h / -78 °C

11.1: DDQ / CH₂Cl₂ / 0.17 h / 23 °C / pH 7

12.1: TMSOTf; Et₃SiH / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; triethylsilane; ethandithiol; lithium aluminium tetrahydride; aluminium trichloride; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; boron trifluoride diethyl etherate; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; dimethyl sulfoxide; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/j.tetlet.2005.09.164