Canagliflozin Impurity 10

Base Information

• Chemical Name: Canagliflozin Impurity 10
• CAS No.: 1672658-93-3
• Molecular Formula: C₂₄H₂₅FO₆S
• Molecular Weight: 460.523
• Mol file: 1672658-93-3.mol

Synonyms:

Chemical Property of Canagliflozin Impurity 10

Chemical Property:

Purity/Quality:

HPLC ≥ 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Canagliflozin Impurity 10

There total 3 articles about Canagliflozin Impurity 10 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide (1030825-20-7) + C18H42O6Si4 → C24H25FO6S (1672658-93-3)

Guidance literature:

3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -60 - -50 ℃; for 0.833333h; Inert atmosphere;

C₁₈H₄₂O₆Si₄; In tetrahydrofuran; hexane; at -50 ℃; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol; at 0 - 20 ℃;

Reference yield: 75.0%

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene) (898566-17-1) + C18H42O6Si4 → C24H25FO6S (1672658-93-3)

Guidance literature:

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene); With n-butyllithium; In tetrahydrofuran; hexane; at -60 - -50 ℃; for 0.833333h; Inert atmosphere;

C₁₈H₄₂O₆Si₄; In tetrahydrofuran; hexane; at -50 ℃; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol; at 0 - 20 ℃;

Reference yield:

D-Glucono-1,5-lactone (90-80-2,1335-57-5,4253-68-3) → C24H25FO6S (1672658-93-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -60 - -50 °C / Inert atmosphere

2.2: -50 °C / Inert atmosphere

2.3: 0 - 20 °C

With dmap; n-butyllithium; In tetrahydrofuran; hexane;

upstream raw materials:

D-Glucono-1,5-lactone

3-[[5-(4-fluorophenyl)-2-thienyl]methyl]-4-methylphenyl bromide

(2-(4-fluorophenyl)-5-[(5-iodo-2-methylphenyl)methyl]thiophene)

Downstream raw materials:

canagliflozin