2-({11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl}-amino)-benzoic acid

Base Information

• Chemical Name: 2-({11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl}-amino)-benzoic acid
• CAS No.: 142535-64-6
• Molecular Formula: C₃₃H₂₇N₃O₄
• Molecular Weight: 529.595
• Mol file: 142535-64-6.mol

Synonyms:

Chemical Property of 2-({11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl}-amino)-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-({11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl}-amino)-benzoic acid

There total 2 articles about 2-({11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl}-amino)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium (E)-11-<2-(5,6-dimethyl-1-benzimidazolyl)ethylidene>-6,11-dihydrodibenzoxepin-2-carboxylate monohydrate (127166-41-0) → 2-({11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl}-amino)-benzoic acid (142535-64-6)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride, Et₃N / CH₂Cl₂ / 5 h / Ambient temperature

2: CH₂Cl₂ / 5 h / Ambient temperature

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00096a017

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) + 11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl chloride → 2-({11-[2-(5,6-Dimethyl-benzoimidazol-1-yl)-eth-(E)-ylidene]-6,11-dihydro-dibenzo[b,e]oxepine-2-carbonyl}-amino)-benzoic acid (142535-64-6)

Guidance literature:

In dichloromethane; for 5h; Ambient temperature;

DOI:10.1021/jm00096a017

upstream raw materials:

anthranilic acid

sodium (E)-11-<2-(5,6-dimethyl-1-benzimidazolyl)ethylidene>-6,11-dihydrodibenzoxepin-2-carboxylate monohydrate