127166-41-0Relevant academic research and scientific papers
Improved synthesis of thromboxane A2 receptor antagonists with a dibenzoxepin ring system
Sugaya,Kato,Sakaguchi,Tomioka
, p. 1257 - 1262 (2007/10/02)
Two derivatives of sodium (E)-11-[2-(1-benzimidazolyl)ethylidene]11-oxo-6,11-dihydrodibenz[b,e]o xepin-2-carboxylate, novel nonprostanoid thromboxane A2 (TXA2) receptor antagonists, were synthesized from methyl 11-oxo-6,11-dihydrodibenz[b,e]oxepin-2-carboxylate. The carbonyl group at C11 was converted into a formylmethylene, then into a 1-azadiene moiety by reaction with a 2-aminoformanilide derivative. Stereo- and regioselective elaboration of the unsymmetrical imidazoles was achieved through a sequence of the transformation of E,Z-1-azadiene intermediates to E isomers under acidic conditions followed by cyclization to imidazoles.
Stereoselective Synthesis of Novel Thromboxane A2 Receptor Antagonists via Stereoselective 1-Azadiene Isomerization
Sugaya, Toru,Kato, Nobuyuki,Tomioka, Shinjii,Tamaki, Kentaro
, p. 2181 - 2182 (2007/10/02)
Novel non-prostanoid thromboxane A2 receptor antagonists were synthesized stereoselectively using the transformation of (E,Z)-1-azadiene intermediates to the only (E) isomers under acidic conditions.
