(-)-(1S)-bis-m-xylylenediamine

Base Information

• Chemical Name: (-)-(1S)-bis-m-xylylenediamine
• CAS No.: 155906-85-7
• Molecular Formula: C₄₄H₅₂N₂O₂
• Molecular Weight: 640.909
• Mol file: 155906-85-7.mol

Synonyms:

Chemical Property of (-)-(1S)-bis-m-xylylenediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-(1S)-bis-m-xylylenediamine

There total 5 articles about (-)-(1S)-bis-m-xylylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

(S)-2-{[1-(3-{[(E)-(S)-1-(Hydroxy-diphenyl-methyl)-3-methyl-butylimino]-methyl}-phenyl)-meth-(E)-ylidene]-amino}-4-methyl-1,1-diphenyl-pentan-1-ol (155906-83-5) → (-)-(1S)-bis-m-xylylenediamine (155906-85-7)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Heating;

DOI:10.1016/S0957-4166(00)80484-X

Reference yield:

Isophthalaldehyde (626-19-7) → (-)-(1S)-bis-m-xylylenediamine (155906-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / molecular sieves / CH₂Cl₂ / Ambient temperature

2: 50 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; molecular sieve; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(00)80484-X

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → (-)-(1S)-bis-m-xylylenediamine (155906-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 62 percent / tetrahydrofuran / 4 h / 0 °C

2: 100 percent / molecular sieves / CH₂Cl₂ / Ambient temperature

3: 50 percent / LiAlH₄ / tetrahydrofuran / Heating

With lithium aluminium tetrahydride; molecular sieve; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0957-4166(00)80484-X

upstream raw materials:

(S)-2-{[1-(3-{[(E)-(S)-1-(Hydroxy-diphenyl-methyl)-3-methyl-butylimino]-methyl}-phenyl)-meth-(E)-ylidene]-amino}-4-methyl-1,1-diphenyl-pentan-1-ol

Isophthalaldehyde

methyl (L)-leucinate hydrochloride

phenylmagnesium bromide