1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
CAS No.:1352234-64-0
Molecular Formula:C₃₄H₃₆N₂O₇
Molecular Weight:584.669
Hs Code.:

Synonyms:

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Chemical Property of 1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

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Technology Process of 1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

There total 31 articles about 1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103763-12-8,103763-13-9
5-O-tert-butyldiphenylsilyl-α,β-L-arabinofuranose

: 1352234-64-0
1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 15 steps

1.1: copper(II) sulfate / sulfuric acid

2.1: sodium hydride; tetrabutyl ammonium fluoride / N,N-dimethyl-formamide; tetrahydrofuran

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran

4.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide; pyridine / dichloromethane; dimethyl sulfoxide

5.1: boron trifluoride diethyl etherate / dichloromethane / -78 °C

6.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran

7.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane

8.1: pyridinium chlorochromate

9.1: L-proline

10.1: dmap; 1,1'-Thiocarbonyldiimidazole / dichloromethane

10.2: 100 °C

11.1: dowex 50W₈X

12.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile

13.1: potassium carbonate; methanol

14.1: 1,1'-Thiocarbonyldiimidazole

15.1: hydrogen / 10 wt% Pd(OH)2 on carbon / tetrahydrofuran; methanol

With pyridine; methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; boron trifluoride diethyl etherate; sulfur trioxide; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; potassium carbonate; copper(II) sulfate; N-ethyl-N,N-diisopropylamine; 1,1'-Thiocarbonyldiimidazole; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; L-proline; sulfuric acid; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 103763-14-0
(3aR,5S,6S,6aR)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-ol

: 1352234-64-0
1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 14 steps

1.1: sodium hydride; tetrabutyl ammonium fluoride / N,N-dimethyl-formamide; tetrahydrofuran

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran

3.1: N-ethyl-N,N-diisopropylamine; sulfur trioxide; pyridine / dichloromethane; dimethyl sulfoxide

4.1: boron trifluoride diethyl etherate / dichloromethane / -78 °C

5.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran

6.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone; water / dichloromethane

7.1: pyridinium chlorochromate

8.1: L-proline

9.1: dmap; 1,1'-Thiocarbonyldiimidazole / dichloromethane

9.2: 100 °C

10.1: dowex 50W₈X

11.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile

12.1: potassium carbonate; methanol

13.1: 1,1'-Thiocarbonyldiimidazole

14.1: hydrogen / 10 wt% Pd(OH)2 on carbon / tetrahydrofuran; methanol

With pyridine; methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; boron trifluoride diethyl etherate; sulfur trioxide; tetrabutyl ammonium fluoride; water; hydrogen; sodium hydride; potassium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-Thiocarbonyldiimidazole; pyridinium chlorochromate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; L-proline; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1352234-56-0
1,2-O-isopropylidene-3-keto-5-O-benzyl-6-deoxy-6-C-acetyl-β-L-altrofuranose

: 1352234-64-0
1-((2R,3aR,7S,7aS)-7-(bis(4-methoxyphenyl)(phenyl)methoxy)-3a-hydroxyoctahydrobenzofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 7 steps

1.1: L-proline

2.1: dmap; 1,1'-Thiocarbonyldiimidazole / dichloromethane

2.2: 100 °C

3.1: dowex 50W₈X

4.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile

5.1: potassium carbonate; methanol

6.1: 1,1'-Thiocarbonyldiimidazole

7.1: hydrogen / 10 wt% Pd(OH)2 on carbon / tetrahydrofuran; methanol

With methanol; dmap; N,O-bis-(trimethylsilyl)-acetamide; hydrogen; potassium carbonate; 1,1'-Thiocarbonyldiimidazole; L-proline; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;