rac-2-amino-4-(4-fluorophenyl)butanoic acid

Base Information

• Chemical Name: rac-2-amino-4-(4-fluorophenyl)butanoic acid
• CAS No.: 225233-79-4
• Molecular Formula: C₁₀H₁₂FNO₂
• Molecular Weight: 197.209
• Hs Code.: 2922498590

Synonyms:

Chemical Property of rac-2-amino-4-(4-fluorophenyl)butanoic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-amino-4-(4-fluorophenyl)butanoicAcid ^*data from reagent suppliers

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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of rac-2-amino-4-(4-fluorophenyl)butanoic acid

There total 5 articles about rac-2-amino-4-(4-fluorophenyl)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

3-(4-fluorophenyl)propanal (63416-70-6) + sodium cyanide (143-33-9,25596-52-5) → rac-2-amino-4-(4-fluorophenyl)butanoic acid (225233-79-4)

Guidance literature:

3-(4-fluorophenyl)propanal; sodium cyanide; With ammonium hydroxide; ammonium chloride; In ethanol; at 20 ℃; for 24h;

With hydrogenchloride; In ethanol; for 6h; Heating;

DOI:10.1002/ejoc.200600454

Reference yield:

ethyl 4-fluorocinnamate (136265-10-6,352-03-4,24393-50-8) → rac-2-amino-4-(4-fluorophenyl)butanoic acid (225233-79-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 94 percent / H₂ / Pd/C / ethyl acetate / 750.06 Torr

2.1: 81 percent / LiAlH₄ / diethyl ether / 20 h

3.1: 63 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 h / 20 °C

4.1: NH₄Cl; aq. NH₃ / ethanol / 24 h / 20 °C

4.2: 11 percent / aq. HCl / ethanol / 6 h / Heating

With ammonium hydroxide; lithium aluminium tetrahydride; hydrogen; ammonium chloride; pyridinium chlorochromate; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; ethyl acetate;

DOI:10.1002/ejoc.200600454

Reference yield:

4-fluorobenzaldehyde (459-57-4) → rac-2-amino-4-(4-fluorophenyl)butanoic acid (225233-79-4)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 93 percent / NaH / 1,2-dimethoxy-ethane / 21 h / 20 °C

2.1: 94 percent / H₂ / Pd/C / ethyl acetate / 750.06 Torr

3.1: 81 percent / LiAlH₄ / diethyl ether / 20 h

4.1: 63 percent / pyridinium chlorochromate / CH₂Cl₂ / 20 h / 20 °C

5.1: NH₄Cl; aq. NH₃ / ethanol / 24 h / 20 °C

5.2: 11 percent / aq. HCl / ethanol / 6 h / Heating

With ammonium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydride; ammonium chloride; pyridinium chlorochromate; palladium on activated charcoal; In 1,2-dimethoxyethane; diethyl ether; ethanol; dichloromethane; ethyl acetate;

DOI:10.1002/ejoc.200600454

upstream raw materials:

3-(4-fluorophenyl)propanal

sodium cyanide

ethyl 3-(4-fluorophenyl)propanoate

ethyl 4-fluorocinnamate

Downstream raw materials:

rac-2-hydroxy-4-(4-fluorophenyl)butanoic acid

(R)-2-hydroxy-4-(4-fluorophenyl)butanoic acid

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