Sofosbuvir IMpurity C 1337482-15-1

Base Information

Chemical Name:Sofosbuvir IMpurity C 1337482-15-1
CAS No.:1337482-15-1
Molecular Formula:C₂₂H₂₉FN₃O₉P
Molecular Weight:529.459
Hs Code.:
Mol file:1337482-15-1.mol

Synonyms:

Suppliers and Price of Sofosbuvir IMpurity C 1337482-15-1

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sofosbuvir5''-Desphosphate3''-O-[(S)-Phosphate]
5mg
$ 195.00

Medical Isotopes, Inc.
Sofosbuvir5??-Desphosphate3??-O-[(S)-Phosphate]
50 mg
$ 2400.00

Total 16 raw suppliers

Chemical Property of Sofosbuvir IMpurity C 1337482-15-1

Chemical Property:

PKA:9.39±0.10(Predicted)
Density:1.41±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Sofosbuvir5''-Desphosphate3''-O-[(S)-Phosphate] ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Sofosbuvir 5''-Desphosphate 3''-O-[(S)-Phosphate] is an impurity of PSI-7977 (P839640), a prodrug that is metabolized to the active antiviral agent 2''-deoxy-2''-α-fluoro-β-C-methyluridine-5''-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Technology Process of Sofosbuvir IMpurity C 1337482-15-1

There total 7 articles about Sofosbuvir IMpurity C 1337482-15-1 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1627824-09-2
(R)-2-((R)-(2,3,4,5,6-pentafluorophenoxy)phenoxyphosphorylamino)propionic acid isopropyl ester

: 1337482-15-1
C₂₂H₂₉FN₃O₉P

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃;
DOI:10.1039/c6sc05081f

Reference yield: 92.0%

: 1337482-15-1
C₂₂H₂₉FN₃O₉P

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0 ℃; for 3h;

Reference yield: 53.0%

: 863329-66-2,2041584-99-8
2'-deoxy-2'-fluoro-2'-methyluridine

: 1334513-02-8,1627824-09-2
(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1337482-15-1
C₂₂H₂₉FN₃O₉P

Guidance literature:: 2'-deoxy-2'-fluoro-2'-methyluridine; tert-butyldimethylsilyl chloride; With pyridine; In dichloromethane;

(S)-2-[(S)-((2,3,4,5,6-pentafluorophenoxy)(phenoxy)phosphoryl)amino]propionic acid isopropyl ester; With tert-butylmagnesium chloride; In tetrahydrofuran;