(5R)-selenapenem

Base Information

Chemical Name:(5R)-selenapenem
CAS No.:107668-59-7
Molecular Formula:C₁₆H₁₆N₂O₆Se
Molecular Weight:411.273
Hs Code.:

Synonyms:

Suppliers and Price of (5R)-selenapenem

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Chemical Property of (5R)-selenapenem

Chemical Property:

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Technology Process of (5R)-selenapenem

There total 6 articles about (5R)-selenapenem which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 94944-10-2
(3R,4R)-4-benzoyloxy-3-<(1R)-(1-tert-butyldimethylsiloxy)ethyl>-azetidin-2-one

: 107668-59-7
(5R)-selenapenem

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / NaH / dimethylformamide

2: 83 percent / Cs₂CO₃ / acetonitrile / overnight

3: 75 percent / LiN(SiMe₃)2 / tetrahydrofuran / 0.5 h / -78 °C

4: 90 percent / NEt₃ / CH₂Cl₂ / -20 °C

5: 80 percent / BF₃*Et₂O / acetonitrile / -15 °C

6: 41 percent / Cl₂ / CCl₄; CH₂Cl₂ / 0.5 h / -40 °C

7: 14 percent / sodium selenide

With sodium selenide; boron trifluoride diethyl etherate; chlorine; sodium hydride; caesium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/S0040-4039(00)84711-5

Reference yield:

: 107668-54-2
(3S,4R)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-4-butylsulfanyl-azetidin-2-one

: 107668-59-7
(5R)-selenapenem

Guidance literature:: Multi-step reaction with 6 steps

1: 83 percent / Cs₂CO₃ / acetonitrile / overnight

2: 75 percent / LiN(SiMe₃)2 / tetrahydrofuran / 0.5 h / -78 °C

3: 90 percent / NEt₃ / CH₂Cl₂ / -20 °C

4: 80 percent / BF₃*Et₂O / acetonitrile / -15 °C

5: 41 percent / Cl₂ / CCl₄; CH₂Cl₂ / 0.5 h / -40 °C

6: 14 percent / sodium selenide

With sodium selenide; boron trifluoride diethyl etherate; chlorine; caesium carbonate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)84711-5

Reference yield:

: 107668-55-3
{(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-butylsulfanyl-4-oxo-azetidin-1-yl}-acetic acid 4-nitro-benzyl ester

: 107668-59-7
(5R)-selenapenem

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / LiN(SiMe₃)2 / tetrahydrofuran / 0.5 h / -78 °C

2: 90 percent / NEt₃ / CH₂Cl₂ / -20 °C

3: 80 percent / BF₃*Et₂O / acetonitrile / -15 °C

4: 41 percent / Cl₂ / CCl₄; CH₂Cl₂ / 0.5 h / -40 °C

5: 14 percent / sodium selenide

With sodium selenide; boron trifluoride diethyl etherate; chlorine; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)84711-5