AF-toxin II_c

Base Information

• Chemical Name: AF-toxin II_c
• CAS No.: 104363-99-7
• Molecular Formula: C₁₇H₂₄O₆
• Molecular Weight: 324.374
• Mol file: 104363-99-7.mol

Synonyms:

Chemical Property of AF-toxin II_c

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of AF-toxin II_c

There total 17 articles about AF-toxin II_c which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-isoleucine (73-32-5,959215-79-3,18875-42-8) → AF-toxin IIc (104363-99-7,104420-16-8,104420-17-9,105089-13-2,108102-60-9)

Guidance literature:

Multi-step reaction with 8 steps

1: sodium nitrite

2: p-toluenesulphonic acid

3: lithium carbonate, water / methanol

4: imidazole / dimethylformamide

5: H₂ / palladium on carbon / ethanol

6: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

7: sodium hydride / aq. ethanol / Ambient temperature

8: tetrabutylammonium fluoride

With 1H-imidazole; tetrabutyl ammonium fluoride; water; hydrogen; lithium carbonate; sodium hydride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; sodium nitrite; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.34.2668

Reference yield:

(2S,3S)-2-(acetyloxy)-3-methylpentanoic acid (104973-58-2) → AF-toxin IIc (104363-99-7,104420-16-8,104420-17-9,105089-13-2,108102-60-9)

Guidance literature:

Multi-step reaction with 7 steps

1: p-toluenesulphonic acid

2: lithium carbonate, water / methanol

3: imidazole / dimethylformamide

4: H₂ / palladium on carbon / ethanol

5: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

6: sodium hydride / aq. ethanol / Ambient temperature

7: tetrabutylammonium fluoride

With 1H-imidazole; tetrabutyl ammonium fluoride; water; hydrogen; lithium carbonate; sodium hydride; 4-pyrrolidin-1-ylpyridine; toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.34.2668

Reference yield:

benzyl (2S,3S)-2-acetoxy-3-methylpentanoate (104855-40-5) → AF-toxin IIc (104363-99-7,104420-16-8,104420-17-9,105089-13-2,108102-60-9)

Guidance literature:

Multi-step reaction with 6 steps

1: lithium carbonate, water / methanol

2: imidazole / dimethylformamide

3: H₂ / palladium on carbon / ethanol

4: dicyclohexylcarbodiimide, 4-pyrrolidinopyridine / CH₂Cl₂

5: sodium hydride / aq. ethanol / Ambient temperature

6: tetrabutylammonium fluoride

With 1H-imidazole; tetrabutyl ammonium fluoride; water; hydrogen; lithium carbonate; sodium hydride; 4-pyrrolidin-1-ylpyridine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1248/cpb.34.2668

upstream raw materials:

(2E,4E,6E)-(R)-8-[(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-3-methyl-pentanoyloxy]-8-((S)-2-methyl-oxiranyl)-octa-2,4,6-trienoic acid

L-isoleucine

4-(tert-Butyldiphenylsiloxy)-5-methylhexa-2(E),5-dienal

4-(tert-Butyldiphenylsiloxy)-5-methylhexa-2(E),5-dien-1-ol

Refernces