(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ⁴-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

Base Information

• Chemical Name: (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ⁴-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester
• CAS No.: 201285-58-7
• Molecular Formula: C₄₀H₄₀N₂O₁₀S
• Molecular Weight: 740.831

Synonyms:

Chemical Property of (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ⁴-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ⁴-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

There total 7 articles about (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ⁴-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester (201285-56-5) → (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ4-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester (201285-58-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/S0040-4039(97)10431-2

Reference yield:

tioxolone (4991-65-5) → (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ4-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester (201285-58-7)

Guidance literature:

Multi-step reaction with 6 steps

1: BF₃*Et₂O / tetrahydrofuran / 0.25 h / Ambient temperature

2: 70 percent / K₂CO₃, CH₂Br₂ / butan-2-one / 48 h / Heating

3: POCl₃ / 1,2-dichloro-ethane / 12 h / from 0 deg C to RT

4: KOH, NaBH₄ / H₂O; ethanol / 0.25 h / Ambient temperature

5: Na₂CO₃ / H₂O; dioxane

6: 3-chloroperoxybenzoic acid / CH₂Cl₂

With potassium hydroxide; sodium tetrahydroborate; boron trifluoride diethyl etherate; sodium carbonate; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; 1,1-dibromomethane; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; 1,2-dichloro-ethane; butanone;

DOI:10.1016/S0040-4039(97)10431-2

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → (S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-3-oxo-2,3-dihydro-3λ4-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester (201285-58-7)

Guidance literature:

Multi-step reaction with 3 steps

1: KOH, NaBH₄ / H₂O; ethanol / 0.25 h / Ambient temperature

2: Na₂CO₃ / H₂O; dioxane

3: 3-chloroperoxybenzoic acid / CH₂Cl₂

With potassium hydroxide; sodium tetrahydroborate; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; ethanol; dichloromethane; water;

DOI:10.1016/S0040-4039(97)10431-2

upstream raw materials:

(S)-N-((S)-1-Carboxy-2-phenyl-ethyl)-3-(9H-fluoren-9-ylmethoxycarbonylamino)-N-(6-hydroxy-benzo[1,3]oxathiol-5-ylmethyl)-succinamic acid tert-butyl ester

tioxolone

L-phenylalanine

6-tert-butoxy-1,3-benzoxathiole

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