6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline

Base Information

Chemical Name:6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline
CAS No.:762199-99-5
Molecular Formula:C₁₉H₁₇Cl₂NO₃
Molecular Weight:378.255
Hs Code.:

Synonyms:

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Chemical Property of 6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of 6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline

There total 5 articles about 6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103959-62-2
2-benzoyl-6,7-dichloro-1-cyano-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline

: 762199-99-5
6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline

Guidance literature:: With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In toluene; for 1.5h; Heating;
DOI:10.1021/jm00161a039

Reference yield:

: 75416-52-3
6,7-dichloro-1,2,3,4-tetrahydroisoquinoline

: 762199-99-5
6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1: 10percent Pd/C / various solvent(s) / 16 h / Heating

2: 18-crown-6 / CH₂Cl₂; H₂O / 0.5 h

3: CH₂Cl₂; H₂O / 3 h / 25 °C

4: 98 percent / benzyl triethylammonium chloride, 50percent aq. NaOH / toluene / 2 h / 25 °C

5: benzyl triethylammonium chloride, 50percent aq. NaOH / toluene / 1.5 h / Heating

With sodium hydroxide; palladium on activated charcoal; 18-crown-6 ether; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; toluene;
DOI:10.1021/jm00161a039

Reference yield:

: 444898-81-1
6,7-dichloroisoquinoline

: 762199-99-5
6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 18-crown-6 / CH₂Cl₂; H₂O / 0.5 h

2: CH₂Cl₂; H₂O / 3 h / 25 °C

3: 98 percent / benzyl triethylammonium chloride, 50percent aq. NaOH / toluene / 2 h / 25 °C

4: benzyl triethylammonium chloride, 50percent aq. NaOH / toluene / 1.5 h / Heating

With sodium hydroxide; 18-crown-6 ether; N-benzyl-N,N,N-triethylammonium chloride; In dichloromethane; water; toluene;
DOI:10.1021/jm00161a039