75416-52-3

Usage

Uses

Used in Pharmaceutical Research:
6,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE is used as a research compound for investigating its potential therapeutic effects on mood disorders and addiction. It is being studied to understand its impact on the central nervous system and its potential as a treatment for these conditions.
Used in Neurodegenerative Disease Research:
In the field of neurodegenerative disease research, 6,7-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE is used as a potential treatment for Parkinson's disease. Its effects on the central nervous system are being explored to determine if it can provide relief or slow the progression of this condition.

Upstream product

• 444898-81-1 6,7-dichloroisoquinoline 
• 73261-87-7 2-acetyl-6,7-dichloro-1,2,3,4-tetrahydroisoquinoline 
• 73075-49-7 6,7-dichloro-1,2,3,4-tetrahydroisoquinoline hydrochloride 
• 21581-45-3 2-(3,4-dichlorophenyl)ethanamine 
• 1099001-52-1 [2-(3,4-dichloro-phenyl)-ethyl]-carbamic acid ethyl ester 
• 6287-38-3 3,4-dichlorobenzaldehyde 
• 73274-27-8 [1-(3,4-Dichloro-phenyl)-meth-(Z)-ylidene]-(2,2-dimethoxy-ethyl)-amine 
• 75416-49-8 2-(3,4-dichloro-benzylamino)-ethanol; hydrochloride 
• 115706-19-9 6,7-dichloro-1,2,3,4-tetrahydro-1-oxoisoquinoline 
• 90273-67-9 3-(3,4-dichlorophenyl)propionic acid chloride 
• 115706-18-8 1,2-dichloro-4-(2-isocyanatoethyl)benzene 
• 25173-68-6 3(3,4-dichlorophenyl)propanoic acid 
• 95-76-1 m,p-dichloroaniline 
• 115706-16-6 methyl 2-bromo-3-(3,4-dichlorophenyl)propionate 

Downstream Products

• 103959-61-1 2-benzoyl-6,7-dichloro-1-cyano-1,2-dihydroisoquinoline 
• 103959-62-2 2-benzoyl-6,7-dichloro-1-cyano-1-(3,4,5-trimethoxybenzyl)-1,2-dihydroisoquinoline 
• 762199-99-5 6,7-dichloro-1-(3,4,5-trimethoxybenzyl)isoquinoline 
• 1150310-59-0 (S)-4-(3-(6,7-dichloro-3,4-dihydroisoquinolin-2(1H)-yl)-2-oxopyrrolidin-1-yl)-N-(thiazol-2-yl)benzenesulfonamide 

Relevant academic research and scientific papers

Catalyst-free cyclization of anthranils and cyclic amines: One-step synthesis of rutaecarpine

An efficient synthesis of a variety of quinazolinone derivatives via a direct cyclization reaction between commercially available anthranils and cyclic amines is described. The developed transformation proceeds with the merits of high step- and atom-efficiency, a broad substrate scope, and good to excellent yields, without additional catalysts, and offers a practical way for the preparation of rutaecarpine and its derivatives with structural diversity.

Benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs

The invention discloses a benzo-aza-alkyl aryl piperazine derivative and applications in preparation of drugs. The derivative shows the effect on central nervous systems, especially on the double highaffinity activity of a 5-HT acceptor and a Sigma-1 acceptor. Various physiological and pharmacological effects are brought into play in the body; and the compound can be used as a pharmaceuticalactive substance, especially used for anti-depression, anti-anxiety, anti-bipolar affective disorder and anti-neuropathic pain, and can also be used as an intermediate to prepare other pharmaceuticalactive compounds. The compound is fast in effect and small in toxic and side effect, and can meet demands of clinical applications; and the compound is a compound or a free base or salt thereof havingthe following structural formula (IV). The structure of the compound or the free base or salt thereof is shown as the structural formula (IV).

HETEROCYCLIC DERIVATIVES AS MODULATORS OF ION CHANNELS

The present invention relates to heterocyclic derivatives useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.

MELANIN CONCENTRATING HORMONE RECEPTOR LIGANDS: SUBSTITUTED TETRAHYDROISOQUINOLINE ANALOGUES

Melanin concentrating hormone receptor ligands (especially substituted tetrahydroisoquinoline analogues), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).

Inhibitors of phenylethanolamine N-methyltransferase and epinephrine biosynthesis: I. Chloro-substituted 1,2,3,4-tetrahydroisoquinolines

In a search for inhibitors of epinephrine biosynthesis as potential therapeutic agents, a series of 13 ring-chlorinated 1,2,3,4-tetrahydroisoquinolines was prepared. These compounds were tested initially for their ability to inhibit rabbit adrenal phenylethanolamine N-methyltransferase (PNMT) in vitro. Enzyme-inhibitor dissociation constants, determined for the six most potent members of the series, indicated the following order of decreasing potency: 7,8-Cl2>6,7,8-Cl3>7-Cl~8-Cl>5,6,7,8-Cl4>5,7,8-Cl3. These compounds were subsequently examined for PNMT-inhibiting activity in intact rats and mice. 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline (SK&F 64139) was the most potent member of the series both in vitro and in vivo and is currently undergoing clinical investigation.

INTRAMOLECULAR FRIEDEL-CRAFTS ALKYLATIONS. II. AN EFFICIENT SYNTHESIS OF BIOLOGICALLY ACTIVE 1,2,3,4-TETRAHYDROISOQUINOLINES

A new synthesis of tetrahydroisoquinolines bearing electron withdrawing groups is presented.The scope and mechanism of the reaction are discussed.Many of these tetrahydroisoquinolines are potent inhibitors of the enzyme PNMT.