2-N-[(4-Methoxyphenyl)-diphenylMethyl]-4,6'-O-dibenzyl ent-Entecavir

Base Information

• Chemical Name: 2-N-[(4-Methoxyphenyl)-diphenylMethyl]-4,6'-O-dibenzyl ent-Entecavir
• CAS No.: 1354695-79-6
• Molecular Formula: C₅₃H₄₉N₅O₄
• Molecular Weight: 820.003
• Mol file: 1354695-79-6.mol

Synonyms:

Chemical Property of 2-N-[(4-Methoxyphenyl)-diphenylMethyl]-4,6'-O-dibenzyl ent-Entecavir

Chemical Property:

• Storage Temp.: -20°C Freezer

Purity/Quality:

98% ^*data from raw suppliers

2-N-[(4-Methoxyphenyl)-diphenylmethyl]-4,6’-O-dibenzylent-Entecavir ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 2-N-[(4-Methoxyphenyl)-diphenylmethyl]-4,6’-O-dibenzyl ent-Entecavir is an intermediate in the preparation of ent-Entecavir (E558905).

Technology Process of 2-N-[(4-Methoxyphenyl)-diphenylMethyl]-4,6'-O-dibenzyl ent-Entecavir

There total 24 articles about 2-N-[(4-Methoxyphenyl)-diphenylMethyl]-4,6'-O-dibenzyl ent-Entecavir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

nysted reagent + (2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone (142217-79-6) → 6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylidenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (142217-80-9,1354695-79-6)

Guidance literature:

nysted reagent; With titanium(IV) isopropylate; titanium tetrachloride; In tetrahydrofuran; dichloromethane; at -70 - -60 ℃; for 1h; Inert atmosphere;

(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone; In tetrahydrofuran; dichloromethane; at -60 - 20 ℃; Temperature; Inert atmosphere;

Reference yield: 88.0%

(2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone (142217-79-6) → 6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylidenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (142217-80-9,1354695-79-6)

Guidance literature:

With hydrogenchloride; titanium tetrachloride; zinc; In tetrahydrofuran; dichloromethane; water; at -30 - 20 ℃; Inert atmosphere; Sealed tube; Molecular sieve;

Reference yield:

Nysted’s reagent + (2R,3S,5S)-5-[2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6-benzyloxy-9H-fluoren-9-yl]-3-benzyloxy-2-[(benzyloxy)methyl]cyclopentanone (142217-79-6) → 6-(benzyloxy)-9-((1S,3R,4S)-4-(benzyloxy)-3-((benzyloxy)methyl)-2-methylidenecyclopentyl)-N-((4-methoxyphenyl)diphenylmethyl)-9H-purin-2-amine (142217-80-9,1354695-79-6)

Guidance literature:

With titanium tetrachloride; In tetrahydrofuran; at 0 - 30 ℃; for 3h; Inert atmosphere;

upstream raw materials:

Benzyloxymethyl chloride

5-(benzyloxymethyl)cyclopentadiene

(1R,2S)-2-((benzyloxy)methyl)cyclopent-3-en-1-ol

(1R,2S,3R,5S)-2-((benzyloxy)methyl)-6-oxabicyclo[3.1.0]hexan-3-ol