2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol

Base Information

Chemical Name:2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol
CAS No.:807376-94-9
Molecular Formula:C₁₆H₂₄O₂
Molecular Weight:248.365
Hs Code.:

Synonyms:

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Chemical Property of 2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol

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Technology Process of 2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol

There total 10 articles about 2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 807376-82-5
ethyl 2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]acetate

: 807376-94-9
2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 0.75h;
DOI:10.1081/SCC-200034755

Reference yield:

: 104-92-7
1-bromo-4-methoxy-benzene

: 807376-94-9
2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 85 percent / lithium / tetrahydrofuran / 1 h / sonication

2.1: 97 percent / pyridinium chlorochromate; silica gel / CH₂Cl₂ / 3 h / 20 °C

3.1: magnesium / tetrahydrofuran

3.2: 70 percent / tetrahydrofuran / 4 h / 20 °C

4.1: 83 percent / pyridinium chlorochromate; silica gel / CH₂Cl₂ / 30 h / 20 °C

5.1: 70 percent / sodium borohydride / methanol / 2 h / cooling

6.1: 47 percent / propionic acid / 48 h / 180 °C

7.1: 98 percent / PhCH=RhCl₂(PCy₃)2 / CH₂Cl₂ / 4 h / 20 °C

8.1: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr

9.1: 84 mg / LiAlH₄ / diethyl ether / 0.75 h / 0 - 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; silica gel; lithium; magnesium; propionic acid; pyridinium chlorochromate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 1.1: Barbier coupling / 6.1: Johnson-Claisen orthoester rearrangement;
DOI:10.1081/SCC-200034755

Reference yield:

: 5497-67-6
2,2-dimethyl-4-pentenal

: 807376-94-9
2-[1-(4-methoxyphenyl)-2,2-dimethylcyclopentyl]ethanol

Guidance literature:: Multi-step reaction with 9 steps

1.1: 85 percent / lithium / tetrahydrofuran / 1 h / sonication

2.1: 97 percent / pyridinium chlorochromate; silica gel / CH₂Cl₂ / 3 h / 20 °C

3.1: magnesium / tetrahydrofuran

3.2: 70 percent / tetrahydrofuran / 4 h / 20 °C

4.1: 83 percent / pyridinium chlorochromate; silica gel / CH₂Cl₂ / 30 h / 20 °C

5.1: 70 percent / sodium borohydride / methanol / 2 h / cooling

6.1: 47 percent / propionic acid / 48 h / 180 °C

7.1: 98 percent / PhCH=RhCl₂(PCy₃)2 / CH₂Cl₂ / 4 h / 20 °C

8.1: hydrogen / Pd/C / ethanol / 3 h / 20 °C / 760 Torr

9.1: 84 mg / LiAlH₄ / diethyl ether / 0.75 h / 0 - 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; hydrogen; silica gel; lithium; magnesium; propionic acid; pyridinium chlorochromate; palladium on activated charcoal; Grubbs catalyst first generation; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; 1.1: Barbier coupling / 6.1: Johnson-Claisen orthoester rearrangement;
DOI:10.1081/SCC-200034755