(R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

Base Information

• Chemical Name: (R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid
• CAS No.: 867061-93-6
• Molecular Formula: C₄₃H₆₂N₈O₉S
• Molecular Weight: 867.079
• Mol file: 867061-93-6.mol

Synonyms:

Chemical Property of (R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

There total 1 articles about (R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R)-2-tert-Butoxycarbonylamino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenylpyridin-2-yloxy)-1,1-dimethylpentyl]tetrazol-1-yl}pentanoylamino)propoxy]-ethoxy}ethoxy)propylcarbamoyl]ethanesulfonic Acid (556063-03-7) → (R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid (867061-93-6)

Guidance literature:

With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; for 0.333333h;

DOI:10.1021/jm050383h

Reference yield:

(R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid (867061-93-6) → 2-[2-(2-tert-butoxycarbonylamino-3-sulfo-propionylamino)-3-sulfo-propionylamino]-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

Guidance literature:

Multi-step reaction with 3 steps

1.1: HBTU; DIEA / dimethylformamide

1.2: DIEA / dimethylformamide / 1 h

2.1: 1.03 g / triisopropylsilane; aq. trifluoroacetic acid / CH₂Cl₂ / 0.33 h

3.1: HBTU; DIEA / dimethylformamide

3.2: DIEA / dimethylformamide / 2 h

With chlorotriisopropylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm050383h

Reference yield:

(R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid (867061-93-6) → (2R,5R,8R,11R)-2-amino-32-(5-(6-(4,6-diphenylpyridin-2-yloxy)-2-methylhexan-2-yl)-1H-tetrazol-1-yl)-3,6,9,12,28-pentaoxo-5,8,11-tris(sulfomethyl)-17,20,23-trioxa-4,7,10,13,27-pentaazadotriacontane-1-sulfonic acid

Guidance literature:

Multi-step reaction with 6 steps

1.1: HBTU; DIEA / dimethylformamide

1.2: DIEA / dimethylformamide / 1 h

2.1: 1.03 g / triisopropylsilane; aq. trifluoroacetic acid / CH₂Cl₂ / 0.33 h

3.1: HBTU; DIEA / dimethylformamide

3.2: DIEA / dimethylformamide / 2 h

4.1: 1.01 g / triisopropylsilane; aq. trifluoroacetic acid / CH₂Cl₂ / 0.42 h

5.1: HBTU; DIEA / dimethylformamide

5.2: DIEA / dimethylformamide / 2 h

6.1: 674.8 mg / triisopropylsilane; aq. trifluoroacetic acid / CH₂Cl₂ / 0.42 h

With chlorotriisopropylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm050383h

upstream raw materials:

(2R)-2-tert-Butoxycarbonylamino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenylpyridin-2-yloxy)-1,1-dimethylpentyl]tetrazol-1-yl}pentanoylamino)propoxy]-ethoxy}ethoxy)propylcarbamoyl]ethanesulfonic Acid

Downstream raw materials:

(R)-2-((R)-2-tert-Butoxycarbonylamino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

(R)-2-[(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-3-sulfo-propionylamino]-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid