(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

Base Information

Chemical Name:(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid
CAS No.:556063-06-0
Molecular Formula:C₄₆H₆₇N₉O₁₃S₂
Molecular Weight:1018.22
Hs Code.:

(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

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Chemical Property of (R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

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Technology Process of (R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

There total 3 articles about (R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 556063-04-8
(R)-2-((R)-2-tert-Butoxycarbonylamino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

: 556063-06-0
(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

Guidance literature:: With chlorotriisopropylsilane; trifluoroacetic acid; In dichloromethane; for 0.333333h;
DOI:10.1021/jm050383h

Reference yield:

: 556063-03-7
(2R)-2-tert-Butoxycarbonylamino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenylpyridin-2-yloxy)-1,1-dimethylpentyl]tetrazol-1-yl}pentanoylamino)propoxy]-ethoxy}ethoxy)propylcarbamoyl]ethanesulfonic Acid

: 556063-06-0
(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: triisopropylsilane; aq. trifluoroacetic acid / CH₂Cl₂ / 0.33 h

2.1: HBTU; DIEA / dimethylformamide

2.2: DIEA / dimethylformamide / 1 h

3.1: 1.03 g / triisopropylsilane; aq. trifluoroacetic acid / CH₂Cl₂ / 0.33 h

With chlorotriisopropylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050383h

Reference yield:

: 867061-93-6
(R)-2-Amino-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

: 556063-06-0
(R)-2-((R)-2-Amino-3-sulfo-propionylamino)-2-[3-(2-{2-[3-(5-{5-[5-(4,6-diphenyl-pyridin-2-yloxy)-1,1-dimethyl-pentyl]-tetrazol-1-yl}-pentanoylamino)-propoxy]-ethoxy}-ethoxy)-propylcarbamoyl]-ethanesulfonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: HBTU; DIEA / dimethylformamide

1.2: DIEA / dimethylformamide / 1 h

2.1: 1.03 g / triisopropylsilane; aq. trifluoroacetic acid / CH₂Cl₂ / 0.33 h

With chlorotriisopropylsilane; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm050383h