2-Methoxy-6-MethylbenzaMide

Base Information

• Chemical Name: 2-Methoxy-6-MethylbenzaMide
• CAS No.: 139583-90-7
• Molecular Formula: C9H11NO2
• Molecular Weight: 165.18900
• Hs Code.: 2924297099
• Mol file: 139583-90-7.mol

Synonyms:2-Methoxy-6-methyl-benzamide;2-methoxy-6-methyl-benzoic acid amide;2-Methoxy-6-methyl-benzoesaeure-amid;6-Methoxy-2-methyl-benzamid;

Chemical Property of 2-Methoxy-6-MethylbenzaMide

Chemical Property:

• PSA: 53.31000
• LogP: 1.98670

Purity/Quality:

97% ^*data from raw suppliers

2-Methoxy-6-methylbenzamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Methoxy-6-MethylbenzaMide

There total 4 articles about 2-Methoxy-6-MethylbenzaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

N-propenyl-2-methoxy-6-methylbenzamide (139583-88-3,139583-89-4) → 2-methoxy-6-methylbenzamide (139583-90-7)

Guidance literature:

With acetic acid; at 60 ℃;

DOI:10.1021/jo00035a030

Reference yield:

o-methoxy-N-allylbenzamide (66897-24-3) → 2-methoxy-6-methylbenzamide (139583-90-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / LDA / tetrahydrofuran; hexane / -70 deg C, 10 min, then to 0 deg C

2: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 10 min , then to -70 deg C 2.) THF, to 0 deg C

3: 86 percent / 50 percent aq. acetic acid / 60 °C

With tert.-butyl lithium; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane;

DOI:10.1021/jo00035a030

Reference yield:

N-propenyl-o-methoxybenzamide (139583-86-1,139583-87-2) → 2-methoxy-6-methylbenzamide (139583-90-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) tert-butyllithium / 1.) THF, pentane, -100 deg C, 10 min , then to -70 deg C 2.) THF, to 0 deg C

2: 86 percent / 50 percent aq. acetic acid / 60 °C

With tert.-butyl lithium; acetic acid;

DOI:10.1021/jo00035a030

upstream raw materials:

2-methoxy-6-methyl-benzonitrile

N-propenyl-2-methoxy-6-methylbenzamide

o-methoxy-N-allylbenzamide

N-propenyl-o-methoxybenzamide

Downstream raw materials:

2-methoxy-6-methyl-benzoic acid

3-methoxyphthalic acid

2-methoxy-6-methyl-benzonitrile

Refernces