N1,N8-DIACETYLSPERMIDINE

Base Information

• Chemical Name: N1,N8-DIACETYLSPERMIDINE
• CAS No.: 82414-35-5
• Molecular Formula: C₁₁H₂₃N₃O₂
• Molecular Weight: 229.323
• Mol file: 82414-35-5.mol

Synonyms:

Chemical Property of N1,N8-DIACETYLSPERMIDINE

Chemical Property:

• Melting Point: 91-94°C
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

N1,N8-Diacetylspermidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N1,N8-Diacetylspermidine is a diacetylated derivative of Spermidine (S680400) found in urine and is a novel promising tumor marker for breast and colorectal cancer.

Technology Process of N1,N8-DIACETYLSPERMIDINE

There total 9 articles about N1,N8-DIACETYLSPERMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

N-(3-aminopropyl)-1,4-diaminobutane (124-20-9) + acetonitrile (75-05-8,26809-02-9) → N1,N3-spermidinebis(acetamide) (82414-35-5)

Guidance literature:

With water; dihydridotetrakis(triphenylphosphine)ruthenium; In 1,2-dimethoxyethane; at 160 ℃; for 24h;

DOI:10.1021/ja00284a066

Reference yield: 93.0%

N-(3-aminopropyl)-1,4-diaminobutane (124-20-9) → N1,N3-spermidinebis(acetamide) (82414-35-5)

Guidance literature:

In tetrahydrofuran; for 6h; Ambient temperature;

DOI:10.1016/S0040-4039(00)87048-3

Reference yield: 90.0%

N-acetyl-N-(2-isopropyl-4-oxo-4H-quinazolin-3-yl)acetamide (178244-37-6) → N1,N3-spermidinebis(acetamide) (82414-35-5) + 3-acetylamino-2-isopropylquinazolin-4(3H)-one (144522-58-7)

Guidance literature:

With N-(3-aminopropyl)-1,4-diaminobutane; In dichloromethane;

DOI:10.1039/cc9960001051

upstream raw materials:

N-(3-aminopropyl)-1,4-diaminobutane

acetonitrile

N-acetoxysuccinimide

N-acetyl-N-(2-isopropyl-4-oxo-4H-quinazolin-3-yl)acetamide