(1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopentindene

Chemical Name:(1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopentindene

CAS No.:128638-83-5
Molecular Formula:C₄₃H₅₆O₄SSi₂
Molecular Weight:725.152
Hs Code.:

(1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopent<a>indene

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Chemical Property of (1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopentindene

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Technology Process of (1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopent indene

There total 4 articles about (1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopent indene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 917-54-4
methyllithium

: 128666-75-1
(1S,4R)-4-(t-butyldiphenylsilyloxy)-1-(1-chloromethyl-2-phenyl)-2-phenylsulfonylcyclopent-2-ene

: 128638-83-5
(1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopent indene

Guidance literature:: In diethyl ether; at -15 ℃; for 0.5h;

Reference yield:

: 103-83-3
N,N'-dimethylbenzylamine

: 128638-83-5
(1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopent indene

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) n-BuLi, 2.) 1-chloro-2-iodoethane / 1.) diethyl ether, hexane, RT, 18 h

2: 80 percent / ethyl chloroformate, Et₃N / CH₂Cl₂ / 10 h / -78 - 20 °C

4: 59 percent / diethyl ether / 0.5 h / -15 °C

With n-butyllithium; 1-chloro-2-iodoethane; chloroformic acid ethyl ester; triethylamine; In diethyl ether; dichloromethane;

Reference yield:

: 10175-33-4
1-(2-iodophenyl)-N,N-dimethylmethanamine

: 128638-83-5
(1R,2R,3aS,8aS)-5-(2-t-butyldimethylsilyloxyethyl)-2-t-butyldiphenylsilyloxy-1-methyl-8a-phenylsulfonyl-1,2,3,3a,8,8a-hexahydrocyclopent indene

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / ethyl chloroformate, Et₃N / CH₂Cl₂ / 10 h / -78 - 20 °C

3: 59 percent / diethyl ether / 0.5 h / -15 °C

With chloroformic acid ethyl ester; triethylamine; In diethyl ether; dichloromethane;