Technology Process of (S)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-1,5-dihydro-pyrrol-2-one
There total 19 articles about (S)-1-Benzoyl-5-(1-benzoyl-1H-indol-3-ylmethyl)-3-{3-[2-((4E,6E,8E)-(S)-2,8-dimethyl-deca-4,6,8-trienyl)-[1,3]dioxolan-2-yl]-propionyl}-1,5-dihydro-pyrrol-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 73 percent / i-Bu2AlH
2: 70 percent / LDA
3: 81 percent / H2, AcOH / Pd/C / ethanol
4: 95 percent / NaOEt / ethanol
5: 77 percent / Et3N, DMAP
6: 68 percent / LiN(SiMe3)2
7: 84 percent / LiN(SiMe3)2
8: H2O2, m-chloroperoxybenzoic acid / 1.) -40 deg C, 2.) 0 deg C
With
dmap; hydrogen; dihydrogen peroxide; sodium ethanolate; diisobutylaluminium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; lithium diisopropyl amide;
palladium on activated charcoal;
In
ethanol;
DOI:10.1039/c39860001447
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 81 percent / H2, AcOH / Pd/C / ethanol
2: 95 percent / NaOEt / ethanol
3: 77 percent / Et3N, DMAP
4: 68 percent / LiN(SiMe3)2
5: 84 percent / LiN(SiMe3)2
6: H2O2, m-chloroperoxybenzoic acid / 1.) -40 deg C, 2.) 0 deg C
With
dmap; hydrogen; dihydrogen peroxide; sodium ethanolate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
ethanol;
DOI:10.1039/c39860001447
- Guidance literature:
-
Multi-step reaction with 5 steps
1: hydrogen, acetic acid / 10percent Pd-C / ethanol / 48 h / 760 Torr / Ambient temperature
2: 80 percent / sodium hydride / ethanol / 16 h / Ambient temperature
3: 77 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 / 16 h / Ambient temperature
4: 1.) lithium hexamethyldisilazide, 2.) lithium hexamethyldisilazide / 1.) THF, hexane, -70 deg C, 5 h, 0 deg C, 30 min, 2.) -70 deg C, 3 h
5: 30percent aq. hydrogen peroxide, m-chloroperoxybenzoic acid / CHCl3 / 1.) -50 deg C, 25 min, 2.) 0 deg C, 15 min
With
dmap; hydrogen; dihydrogen peroxide; sodium hydride; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane;
palladium on activated charcoal;
In
ethanol; dichloromethane; chloroform;
