(E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine

Base Information

• Chemical Name: (E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine
• CAS No.: 84163-52-0
• Molecular Formula: C₁₆H₁₉FN₂O₄
• Molecular Weight: 322.336
• Mol file: 84163-52-0.mol

Synonyms:

Chemical Property of (E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine

Chemical Property:

• Solubility.: Acetonitrile, Chloroform, Dichloromethane

Purity/Quality:

99% ^*data from raw suppliers

(E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine is used in the preparation of Risperidone (R525000) impurity.

Technology Process of (E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine

There total 1 articles about (E)-1-Acetyl-N-(acetyloxy)-α-(5-fluoro-2-hydroxyphenyl)-4-piperidinemethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic anhydride (108-24-7) + 1-acetyl-4-(5-fluoro-2-hydroxybenzoyl)piperidine oxime (84162-97-0,84163-60-0) → C16H19FN2O4 (84163-52-0,84163-76-8)

Guidance literature:

at 60 ℃; for 1.5h;

DOI:10.1021/jm00383a012

Reference yield:

C16H19FN2O4 (84163-52-0,84163-76-8) → 4-(5-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride (84163-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 16 h / Ambient temperature

2: 6 N aq. HCl / 6 h / Heating

With hydrogenchloride; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1021/jm00383a012

Reference yield:

C16H19FN2O4 (84163-52-0,84163-76-8) → 3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-5-fluoro-1,2-benzisoxazole (84231-29-8)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide / 16 h / Ambient temperature

2: 6 N aq. HCl / 6 h / Heating

3: NaHCO₃, KI / dimethylformamide / 8 h / 90 °C

With hydrogenchloride; sodium hydride; sodium hydrogencarbonate; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm00383a012

upstream raw materials:

acetic anhydride

1-acetyl-4-(5-fluoro-2-hydroxybenzoyl)piperidine oxime

Downstream raw materials:

3-(1-acetyl-4-piperidinyl)-5-fluoro-1,2-benzisoxazole

4-(5-fluoro-1,2-benzisoxazol-3-yl)piperidine hydrochloride

3-{1-[4,4-bis(4-fluorophenyl)-1-butyl]-4-piperidyl}-5-fluoro-1,2-benzisoxazole