tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate

Base Information

• Chemical Name: tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate
• CAS No.: 124918-18-9
• Molecular Formula: C₃₉H₃₉N₇O₆S₄
• Molecular Weight: 830.046
• Mol file: 124918-18-9.mol

Synonyms:

Chemical Property of tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate

There total 1 articles about tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl diazopyruvate (71901-63-8) → tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate (102142-89-2,124918-17-8,124918-18-9)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂ / 1 h / Ambient temperature

2: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

With triethylamine; In dichloromethane;

DOI:10.3987/COM-88-S127

Reference yield: 26.7%

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-4-hydroxy-1-dethia-2-thiacepham-4-carboxylate (102142-89-2,124918-17-8,124918-18-9) → (6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester (102062-23-7) + tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-1-dethia-2-thia-3-cephem-4-carboxylate (102142-90-5,124918-25-8)

Guidance literature:

With diphosphorus tetraiodide; In pyridine;

DOI:10.3987/COM-88-S127

upstream raw materials:

tert-butyl diazopyruvate

Downstream raw materials:

(6S,7S)-7-{2-[(Z)-Methoxyimino]-2-[2-(trityl-amino)-thiazol-4-yl]-acetylamino}-8-oxo-4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid tert-butyl ester

tert-butyl 7β-<2-(2-tritylaminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido>-3-<(5-methyl-1,3,4-thiadiazol-2-yl)thio>-1-dethia-2-thia-3-cephem-4-carboxylate