(S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Base Information

Chemical Name:(S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester
CAS No.:190187-33-8
Molecular Formula:C₄₀H₄₀N₆O₆
Molecular Weight:700.794
Hs Code.:

(S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Chemical Property of (S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

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Technology Process of (S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

There total 1 articles about (S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 5609-55-2
O-benzylaspartyl-phenylalanine amide

: 139091-30-8,109364-32-1
(S)-benzyl (1-(indol-3-yl)-3-oxopropan-2-yl)carbamate

: 190187-33-8
(S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

: (S)-3-[(1S,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

Guidance literature:: With zinc(II) chloride;
DOI:10.1016/S0960-894X(97)00107-8

Reference yield: 100.0%

: 190187-33-8
(S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

: (S)-2-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: With sodium hydroxide;
DOI:10.1016/S0960-894X(97)00107-8

Reference yield:

: 190187-33-8
(S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid benzyl ester

: (S)-3-[(1R,2S)-2-Benzyloxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

: 190187-42-9
(S)-3-[(1R,2S)-2-Amino-1-cyano-3-(1H-indol-3-yl)-propylamino]-N-((S)-1-carbamoyl-2-phenyl-ethyl)-succinamic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; under 760 Torr; Yield given. Yields of byproduct given; Ambient temperature;
DOI:10.1016/S0960-894X(97)00107-8