(E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester

Base Information

Chemical Name:(E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester
CAS No.:77251-54-8
Molecular Formula:C₄₉H₅₉N₃O₉S
Molecular Weight:866.088
Hs Code.:

(E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester

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Chemical Property of (E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester

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Technology Process of (E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester

There total 9 articles about (E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77251-52-6
(E)-3-{4-Benzyloxy-3-[2-methoxy-4-((E)-2-methoxycarbonyl-vinyl)-phenoxy]-phenyl}-acrylic acid

: 77251-54-8
(E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl chloride

3: 90 percent / tetrahydrofuran / 336 h / Ambient temperature

4: KOH, H₂O / methanol

5: dicyclohexylcarbodiimide / pyridine

With potassium hydroxide; oxalyl dichloride; water; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; methanol;
DOI:10.1016/S0040-4039(00)92847-8

Reference yield:

: 77260-55-0
(E)-3-[4-(2-Benzyloxy-5-formyl-phenoxy)-3-methoxy-phenyl]-acrylic acid methyl ester

: 77251-54-8
(E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / pyridine, piperidine

2: oxalyl chloride

4: 90 percent / tetrahydrofuran / 336 h / Ambient temperature

5: KOH, H₂O / methanol

6: dicyclohexylcarbodiimide / pyridine

With piperidine; pyridine; potassium hydroxide; oxalyl dichloride; water; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; methanol;
DOI:10.1016/S0040-4039(00)92847-8

Reference yield:

: 77251-51-5
Bis-(2-benzyloxy-5-formyl-phenyl)-iodonium; bromide

: 77251-54-8
(E)-3-{4-[2-Benzyloxy-5-((E)-2-{3-[tert-butoxycarbonyl-(4-tert-butoxycarbonylamino-butyl)-amino]-propylcarbamoyl}-vinyl)-phenoxy]-3-methoxy-phenyl}-thioacrylic acid S-phenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 50 percent / Cu, Et₃N / methanol

2: 96 percent / pyridine, piperidine

3: oxalyl chloride

5: 90 percent / tetrahydrofuran / 336 h / Ambient temperature

6: KOH, H₂O / methanol

7: dicyclohexylcarbodiimide / pyridine

With piperidine; pyridine; potassium hydroxide; oxalyl dichloride; water; copper; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; pyridine; methanol;
DOI:10.1016/S0040-4039(00)92847-8