(E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate

Base Information

• Chemical Name: (E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate
• CAS No.: 1430216-98-0
• Molecular Formula: C₂₉H₂₆ClN₉O₆
• Molecular Weight: 632.035
• Mol file: 1430216-98-0.mol

Synonyms:

Chemical Property of (E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate

There total 3 articles about (E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid (942316-73-6) + methyl 4-isocyanophenylcarbamate (1430115-42-6) + 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine (1430217-53-0) → (E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate (1430216-98-0)

Guidance literature:

With methanol; for 24h; Reflux;

Reference yield:

t-butyl 8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (570409-62-0) → (E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate (1430216-98-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; dichloromethane / 1 h / 0 °C

2: iodine; mercury(II) oxide / dichloromethane / 1 h / 0 °C

3: methanol / 24 h / Reflux

With hydrogenchloride; methanol; iodine; mercury(II) oxide; In 1,4-dioxane; dichloromethane;

Reference yield:

8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine (1430217-52-9) → (E)-methyl 4-(6-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamido)phenylcarbamate (1430216-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; mercury(II) oxide / dichloromethane / 1 h / 0 °C

2: methanol / 24 h / Reflux

With methanol; iodine; mercury(II) oxide; In dichloromethane;

upstream raw materials:

(2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]-prop-2-enoic acid

methyl 4-isocyanophenylcarbamate

8,8-dimethyl-3-nitro-7,8-dihydro-1,6-naphthyridine

8,8-dimethyl-3-nitro-5,6,7,8-tetrahydro-1,6-naphthyridine