(+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

Base Information

Chemical Name:(+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid
CAS No.:191285-83-3
Molecular Formula:C₂₆H₃₄Cl₂N₂O₈
Molecular Weight:573.471
Hs Code.:

(+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

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Chemical Property of (+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

Chemical Property:

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Technology Process of (+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

There total 7 articles about (+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5197-62-6
2-[2-(chloroethoxy)ethoxy]ethanol

: 191285-83-3
(+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 89 percent / DMF / 17 h / Heating

2: 90 percent / Jones reagent / acetone / 1 h

3: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

4: 4 h / Heating

5: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

6: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

7: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

8: tetrabutylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; jones reagent; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; N,N-dimethyl-formamide; 1,1'-carbonyldiimidazole; methylamine; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 75001-09-1
2-(2-(2-(1,3-dioxoisoindolin-2-yl)ethoxy)ethoxy)acetic acid

: 191285-83-3
(+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

2: 4 h / Heating

3: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

4: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

5: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

6: tetrabutylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; 1,1'-carbonyldiimidazole; methylamine; In tetrahydrofuran; ethanol;
DOI:10.1016/S0968-0896(97)00024-2

Reference yield:

: 75001-08-0
2-{2-[2-(2-hydroxyethoxy)ethoxy]ethyl}isoindole-1,3-dione

: 191285-83-3
(+)-2-{[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-6-methyl-1,4-dihydropyridine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / Jones reagent / acetone / 1 h

2: 1.) carbonyldiimidazole, 2.) pyridine / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, RT, 48 h

3: 4 h / Heating

4: 41 percent / ammonium formate / ethanol / 72 h / 40 °C

5: 71 percent / 40percent aq. methylamine / 5 h / Ambient temperature

6: 85 percent / aq. K₂CO₃ / tetrahydrofuran / 2 h / 0 °C

7: tetrabutylammonium fluoride / tetrahydrofuran / 24 h / Ambient temperature

With pyridine; jones reagent; tetrabutyl ammonium fluoride; ammonium formate; potassium carbonate; 1,1'-carbonyldiimidazole; methylamine; In tetrahydrofuran; ethanol; acetone;
DOI:10.1016/S0968-0896(97)00024-2