2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine

Base Information

• Chemical Name: 2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine
• CAS No.: 349141-24-8
• Molecular Formula: C₂₃H₂₃NO₄
• Molecular Weight: 377.44
• Mol file: 349141-24-8.mol

Synonyms:

Chemical Property of 2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine

There total 5 articles about 2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl bromide (100-39-0) → 2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine (349141-24-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 80 percent / sodium hydroxide / ethanol / Heating

2: 71 percent / NH₃ / ethanol; H₂O / 168 h / 20 °C

3: 72 percent / triphenyl phosphine; DEAD / tetrahydrofuran / Heating

4: 72 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

5: 130 °C

With sodium hydroxide; ammonia; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1016/S0040-4020(01)00222-8

Reference yield:

3-(benzyloxy)-2-ethyl-4H-pyran-4-one (111782-87-7) → 2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine (349141-24-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / NH₃ / ethanol; H₂O / 168 h / 20 °C

2: 72 percent / triphenyl phosphine; DEAD / tetrahydrofuran / Heating

3: 72 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

4: 130 °C

With ammonia; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; water;

DOI:10.1016/S0040-4020(01)00222-8

Reference yield:

2-ethyl-3-(benzyloxy)-4-hydroxypyridine (143697-02-3,150630-14-1) → 2-(1'-acetoxyethyl)-3,4-dibenzyloxypyridine (349141-24-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / triphenyl phosphine; DEAD / tetrahydrofuran / Heating

2: 72 percent / m-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

3: 130 °C

With 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

DOI:10.1016/S0040-4020(01)00222-8

upstream raw materials:

acetic anhydride

2-ethyl-3,4-dibenzyloxypyridine N-oxide

benzyl bromide

3-(benzyloxy)-2-ethyl-4H-pyran-4-one

Downstream raw materials:

2-(1'-hydroxyethyl)-3,4-dibenzyloxypyridine