Technology Process of 3-cyclohexyl-2-ethylsulfanyl-1H-indole
There total 5 articles about 3-cyclohexyl-2-ethylsulfanyl-1H-indole which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 97 percent / H2 / 10 percent Pd/C / ethanol / 72 h / 100 °C / 38786.1 Torr
2.1: 57 percent / aq. KOH; BnEt3NCl / CH2Cl2 / Heating
3.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
3.2: 73 percent / HMPA / tetrahydrofuran; hexane / -78 - 20 °C
4.1: AIBN / acetonitrile / 0.25 h / 100 °C
With
potassium hydroxide; 2,2'-azobis(isobutyronitrile); N-benzyl-N,N,N-triethylammonium chloride; hydrogen; lithium diisopropyl amide;
10% palladium on active carbon;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; acetonitrile;
3.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1055/s-2001-16808
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 84 percent / KF / tetrahydrofuran / 2 h / 40 °C
2.1: 97 percent / H2 / 10 percent Pd/C / ethanol / 72 h / 100 °C / 38786.1 Torr
3.1: 57 percent / aq. KOH; BnEt3NCl / CH2Cl2 / Heating
4.1: LDA / tetrahydrofuran; hexane / 0.5 h / -78 °C
4.2: 73 percent / HMPA / tetrahydrofuran; hexane / -78 - 20 °C
5.1: AIBN / acetonitrile / 0.25 h / 100 °C
With
potassium fluoride; potassium hydroxide; 2,2'-azobis(isobutyronitrile); N-benzyl-N,N,N-triethylammonium chloride; hydrogen; lithium diisopropyl amide;
10% palladium on active carbon;
In
tetrahydrofuran; ethanol; hexane; dichloromethane; acetonitrile;
4.2: Horner-Wadsworth-Emmons reaction;
DOI:10.1055/s-2001-16808
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile);
In
acetonitrile;
at 100 ℃;
for 0.25h;
DOI:10.1055/s-2001-16808