Technology Process of (S)-7-Benzyloxy-1-(3-benzyloxy-4-methoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester
There total 13 articles about (S)-7-Benzyloxy-1-(3-benzyloxy-4-methoxy-benzyl)-6-methoxy-3,4-dihydro-1H-isoquinoline-2-carboxylic acid ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75 percent / KOH / H2O / 5 h / Heating
2: 93 percent / NaBH4 / ethanol / 1.) room temperature, 18 h, 2.) reflux, 1 h
3: 96 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 °C
4: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h
5: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature
6: K2CO3 / acetone / 14 h / Heating
With
potassium hydroxide; sodium tetrahydroborate; tert.-butyl lithium; phosphorus tribromide; potassium carbonate; acetic acid; hydrazine;
In
tetrahydrofuran; ethanol; water; acetone;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 75 percent / KOH / H2O / 5 h / Heating
2: 93 percent / NaBH4 / ethanol / 1.) room temperature, 18 h, 2.) reflux, 1 h
3: 96 percent / PBr3 / tetrahydrofuran / 1.5 h / 0 °C
4: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h
5: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature
6: K2CO3 / acetone / 14 h / Heating
With
potassium hydroxide; sodium tetrahydroborate; tert.-butyl lithium; phosphorus tribromide; potassium carbonate; acetic acid; hydrazine;
In
tetrahydrofuran; ethanol; water; acetone;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 73 percent / ammonium acetate / 1.5 h / Heating
2: 55 percent / lithium aluminum hydride / diethyl ether; tetrahydrofuran / 1.) reflux, 2 h, 2.) room temperature, overnight
3: formic acid / 48 h / 50 °C
4: 88 percent / ammonium sulfate / toluene / 48 h / Heating
5: t-BuLi / 1.) THF, hexane, -78 deg C, 30 min, 2.) -100 deg C, 4 h
6: hydrazine, acetic acid / ethanol; H2O / 2 h / Ambient temperature
7: K2CO3 / acetone / 14 h / Heating
With
ammonium acetate; ammonium sulfate; lithium aluminium tetrahydride; tert.-butyl lithium; potassium carbonate; acetic acid; hydrazine;
In
tetrahydrofuran; formic acid; diethyl ether; ethanol; water; acetone; toluene;
