2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene

Base Information

Chemical Name:2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene
CAS No.:1514862-86-2
Molecular Formula:C₁₆H₉BrF₂S
Molecular Weight:351.214
Hs Code.:

Synonyms:

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Chemical Property of 2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene

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Technology Process of 2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene

There total 6 articles about 2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193958-89-3
3-(2-fluorophenyl)thiophene

: 1514862-86-2
2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 3 h / 50 °C

2: (1S)-10-camphorsulfonic acid; (tetrahydrothiophene)gold(III) bromide; (4-fluorophenyl)-λ³-iodanediyl diacetate / chloroform-d1; d(4)-methanol / 30 °C / Sealed tube

With N-Bromosuccinimide; (tetrahydrothiophene)gold(III) bromide; (4-fluorophenyl)-λ³-iodanediyl diacetate; (1S)-10-camphorsulfonic acid; acetic acid; In chloroform-d1; chloroform; d⁽⁴⁾-methanol;
DOI:10.1021/ja408712e

Reference yield:

: 1993-03-9
o-fluorophenylboronic acid

: 1514862-86-2
2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; potassium fluoride / tetrahydrofuran / 1 h / 20 °C / Schlenk technique; Inert atmosphere

2: N-Bromosuccinimide; acetic acid / chloroform / 3 h / 50 °C

3: (1S)-10-camphorsulfonic acid; (tetrahydrothiophene)gold(III) bromide; (4-fluorophenyl)-λ³-iodanediyl diacetate / chloroform-d1; d(4)-methanol / 30 °C / Sealed tube

With potassium fluoride; N-Bromosuccinimide; (tetrahydrothiophene)gold(III) bromide; (4-fluorophenyl)-λ³-iodanediyl diacetate; (1S)-10-camphorsulfonic acid; palladium diacetate; acetic acid; In tetrahydrofuran; chloroform-d1; chloroform; d⁽⁴⁾-methanol;
DOI:10.1021/ja408712e

Reference yield:

: 193958-89-3
3-(2-fluorophenyl)thiophene

: 1514863-74-1
C₂₀H₁₀Br₂F₂S₂

: 1514862-86-2
2-bromo-3-(2-fluorophenyl)-5-(4-fluorophenyl)thiophene

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; acetic acid / chloroform / 3 h / 50 °C

2: (1S)-10-camphorsulfonic acid; (4-fluorophenyl)-λ³-iodanediyl diacetate; (triphenylphosphine)gold(I) chloride / chloroform-d1; d(4)-methanol / 1.33 h / 30 °C

With N-Bromosuccinimide; (triphenylphosphine)gold(I) chloride; (4-fluorophenyl)-λ³-iodanediyl diacetate; (1S)-10-camphorsulfonic acid; acetic acid; In chloroform-d1; chloroform; d⁽⁴⁾-methanol;
DOI:10.1021/ja408712e