2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole

Base Information

Chemical Name:2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole
CAS No.:1305348-58-6
Molecular Formula:C₂₂H₁₄N₄
Molecular Weight:334.38
Hs Code.:

Synonyms:

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Chemical Property of 2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole

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Technology Process of 2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole

There total 3 articles about 2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1305348-56-4
4'-(methylamino)-3'-nitro-[1,1'-biphenyl]-4-carbonitrile

: 1305348-58-6
2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 2585.81 Torr

2: sodium hydrogensulfite / N,N-dimethyl-formamide / 48 h / 130 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; sodium hydrogensulfite; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.02.045

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1305348-58-6
2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dichloromethane

2: potassium phosphate; trans-diacetylpalladium(II) bis(dicyclohexylamine) / ethanol / 24 h / 80 °C / Inert atmosphere

3: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 2585.81 Torr

4: sodium hydrogensulfite / N,N-dimethyl-formamide / 48 h / 130 °C / Inert atmosphere

With potassium phosphate; trans-diacetylpalladium(II) bis(dicyclohexylamine); palladium 10% on activated carbon; hydrogen; potassium carbonate; sodium hydrogensulfite; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2011.02.045

Reference yield:

: 53484-26-7
N-methyl-4-bromo-2-nitroaniline

: 1305348-58-6
2,5-bis(4-cyanophenyl)-1-methyl-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; trans-diacetylpalladium(II) bis(dicyclohexylamine) / ethanol / 24 h / 80 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 2585.81 Torr

3: sodium hydrogensulfite / N,N-dimethyl-formamide / 48 h / 130 °C / Inert atmosphere

With potassium phosphate; trans-diacetylpalladium(II) bis(dicyclohexylamine); palladium 10% on activated carbon; hydrogen; sodium hydrogensulfite; In ethanol; ethyl acetate; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1016/j.bmc.2011.02.045