53484-26-7

Basic information

• Product Name: 4-bromo-N-methyl-2-nitroaniline
• Synonyms: 4-bromo-N-methyl-2-nitroaniline
• CAS NO: 53484-26-7
• Molecular Formula: C₇H₇BrN₂O₂
• Molecular Weight: 231.048
• Mol File: 53484-26-7.mol
• Article Data: 30

Chemical Properties

• Melting Point: 97.5-98 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 316.1°C at 760 mmHg
• Flash Point: 144.9°C
• Appearance: /
• Density: 1.687g/cm³
• Vapor Pressure: 0.00042mmHg at 25°C
• Refractive Index: 1.652
• Storage Temp.: 2-8°C(protect from light)
• PKA: -1.68±0.25(Predicted)
• CAS DataBase Reference: 4-bromo-N-methyl-2-nitroaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-N-methyl-2-nitroaniline(53484-26-7)
• EPA Substance Registry System: 4-bromo-N-methyl-2-nitroaniline(53484-26-7)

Safety Data

• Hazardous Substances Data: 53484-26-7(Hazardous Substances Data)

Usage

General Description

4-bromo-N-methyl-2-nitroaniline is a chemical compound with the molecular formula C7H7BrN2O2. It is a derivative of aniline, which is a precursor to many industrial chemicals, including dyes, pharmaceuticals, and rubber processing chemicals. This particular compound is a yellow solid with a molecular weight of 232.05 g/mol. It is used in organic synthesis and as a precursor to other pharmaceuticals and agrochemicals. The substance is flammable and should be handled with care, following all relevant safety precautions.

InChI:InChI=1/C7H7BrN2O2/c1-9-6-3-2-5(8)4-7(6)10(11)12/h2-4,9H,1H3

Upstream product

• 364-73-8 4-Bromo-1-fluoro-2-nitrobenzene 
• 74-89-5 methylamine 
• 875-51-4 4-Bromo-2-nitroaniline 
• 74-88-4 methyl iodide 
• 593-51-1 methylamine hydrochloride 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 88-73-3 2-Chloronitrobenzene 
• 829-02-7 4-Bromo-2-nitro-N,N-dimethylbenzeneamine 
• 6911-87-1 4-bromo-N-methylaniline 
• 7664-93-9 sulfuric acid 
• 860585-07-5 4-bromo-N-methyl-2-nitro-N-nitroso-aniline 
• 57-13-6 urea 
• 23042-33-3 4-bromo-N-methyl-N-nitro-aniline 

Downstream Products

• 84712-08-3 5-bromo-1-methyl-1,3-dihydro-2H-benzo[d]imidazole-2-one 
• 25877-78-5 N-methyl-3-nitro-[1,1'-biphenyl]-4-amine 
• 3527-19-3 1,2-dimethyl-1H-benzo[d]imidazole-5-amine 
• 99513-17-4 5-bromo-1,2-dimethyl-1H-benzo[d]imidazole 
• 1107627-02-0 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole 
• 53484-15-4 5-bromo-1-methyl-1H-benzo[d]imidazole 
• 337915-79-4 4-bromo-N²-methylbenzene-1,2-diamine 
• 760212-72-4 N-(-2-amino-4-bromophenyl)-N-methylbenzamide 
• 1396753-41-5 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d][1,2,3]triazole 
• 944718-31-4 5-bromo-1-methyl-1H-benzo[d][1,2,3]triazole 

Relevant articles and documents

Synthesis of nitric oxide probes with fluorescence lifetime sensitivity

We present the rationale, synthesis and evaluation of the first activatable fluorescent probe that utilizes fluorescence lifetime change for detection of nitric oxide. The new probe DAP-LT1 features a near-infrared polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

1H-BENZO[D]IMIDAZOLE DERIVATIVES AS TLR9 INHIBITORS FOR THE TREATMENT OF FIBROSIS

The present invention relates to lH-benzo[d]imidazole derivatives of formula (I) or a salt thereof. The present compounds are inhibitors of TLR9 and useful in treating preventing, or slowing fibrotic diseases, such as e.g. liver fibrosis, renal fibrosis, biliary fibrosis or pancreatic fibrosis, nonalcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), chronic kidney disease, diabetic kidney disease, primary sclerosing cholangitis (PSC) or primary biliary cirrhosis (PBC), or idiopathic pulmonary fibrosis (IPF).

Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes

CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.