(S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

Base Information

Chemical Name:(S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one
CAS No.:1415995-38-8
Molecular Formula:C₁₈H₂₄N₂O₂
Molecular Weight:300.401
Hs Code.:

Synonyms:

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Chemical Property of (S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

Chemical Property:

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Technology Process of (S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

There total 8 articles about (S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42856-43-9
1-benzylpiperidine-2,6-dione

: 1415995-38-8
(S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

: (R)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydride; ethanol / mineral oil; diethyl ether / 0 - 25 °C / Inert atmosphere

2: triethylamine / 1 h / 0 - 20 °C

3: triethylamine / toluene / 20 h / 125 °C / Inert atmosphere

4: [Rh(COD)(Et-DuPHOS)]BF₄; hydrogen / dichloromethane / 120 h / 20 °C / 18751.9 Torr / Inert atmosphere

5: hydrogenchloride; sodium tetrahydroborate / water / 0 °C / pH 7 / Inert atmosphere

6: trifluoroacetic acid; triethylsilane / dichloromethane / 5 h / 45 °C / Inert atmosphere

7: hydrogen; 5%-palladium/activated carbon / methanol / 20 - 22 °C / 3750.38 Torr

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; ethanol; 5%-palladium/activated carbon; [Rh(COD)(Et-DuPHOS)]BF₄; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; water; toluene; mineral oil;
DOI:10.1039/c2cc36807b

Reference yield:

: 108-55-4
glutaric anhydride,

: 1415995-38-8
(S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

: (R)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: triethylamine / tetrahydrofuran / 24 h / 0 - 75 °C / Inert atmosphere

2: acetyl chloride / 10 h / 65 °C / Inert atmosphere

3: sodium hydride; ethanol / mineral oil; diethyl ether / 0 - 25 °C / Inert atmosphere

4: triethylamine / 1 h / 0 - 20 °C

5: triethylamine / toluene / 20 h / 125 °C / Inert atmosphere

6: 2-hydroxypyridin; triethylamine / toluene / 20 h / 125 °C / Inert atmosphere

7: [Rh(COD)(Et-DuPHOS)]BF₄; hydrogen / dichloromethane / 120 h / 20 °C / 18751.9 Torr / Inert atmosphere

8: hydrogenchloride; sodium tetrahydroborate / water / 0 °C / pH 7 / Inert atmosphere

9: trifluoroacetic acid; triethylsilane / dichloromethane / 5 h / 45 °C / Inert atmosphere

10: hydrogen; 5%-palladium/activated carbon / methanol / 20 - 22 °C / 3750.38 Torr

With 2-hydroxypyridin; hydrogenchloride; triethylsilane; sodium tetrahydroborate; ethanol; 5%-palladium/activated carbon; [Rh(COD)(Et-DuPHOS)]BF₄; hydrogen; sodium hydride; triethylamine; acetyl chloride; trifluoroacetic acid; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; toluene; mineral oil;
DOI:10.1039/c2cc36807b

Reference yield:

: (1-benzyl-2,6-dioxopiperidin-3-ylidene)methyl-11-methylbenzene sulfonate

: 1415995-38-8
(S)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

: (R)-1-((1-benzyl-6-oxopiperidin-3-yl)methyl)piperidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / toluene / 20 h / 125 °C / Inert atmosphere

2: [Rh(COD)(Et-DuPHOS)]BF₄; hydrogen / dichloromethane / 120 h / 20 °C / 18751.9 Torr / Inert atmosphere

3: hydrogenchloride; sodium tetrahydroborate / water / 0 °C / pH 7 / Inert atmosphere

4: trifluoroacetic acid; triethylsilane / dichloromethane / 5 h / 45 °C / Inert atmosphere

5: hydrogen; 5%-palladium/activated carbon / methanol / 20 - 22 °C / 3750.38 Torr

With hydrogenchloride; triethylsilane; sodium tetrahydroborate; 5%-palladium/activated carbon; [Rh(COD)(Et-DuPHOS)]BF₄; hydrogen; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; toluene;
DOI:10.1039/c2cc36807b