42856-43-9

Basic information

• Product Name: N-Benzyl-2,6-piperidinedion
• Synonyms: 1-Benzyl-2,6-piperidinedione;N-(Phenylmethyl)-2,6-piperidinedion;N-Benzyl-2,6-piperidinedion;N-benzyl-2,6-piperidinedione;1-Benzylpiperidine-2,6-dione
• CAS NO: 42856-43-9
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Mol File: 42856-43-9.mol
• Article Data: 22

Chemical Properties

• Melting Point: 48-49 °C
• Boiling Point: 404.6 °C at 760 mmHg
• Flash Point: 195.2 °C
• Appearance: /
• Density: 1.203
• Vapor Pressure: 9.33E-07mmHg at 25°C
• Refractive Index: 1.578
• CAS DataBase Reference: N-Benzyl-2,6-piperidinedion(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzyl-2,6-piperidinedion(42856-43-9)
• EPA Substance Registry System: N-Benzyl-2,6-piperidinedion(42856-43-9)

Safety Data

• Hazardous Substances Data: 42856-43-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H13NO2/c14-11-7-4-8-12(15)13(11)9-10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H2

Upstream product

• 2873-74-7 gloutaric dichloride 
• 52826-45-6 (benzylimino)triphenylphosphorane 
• 42856-45-1 5-oxo-5-[(phenylmethyl)amino]pentanoic acid 
• 622-79-7 benzyl azide 
• 111-29-5 1 ,5-pentanediol 
• 100-46-9 benzylamine 
• 1501-26-4 methyl 4-(chlorocarbonyl)butyrate 
• 3424-60-0 pentanediamide 
• 100-39-0 benzyl bromide 
• 108-55-4 glutaric anhydride, 
• 1121-89-7 piperidine-2,6-dione 

Downstream Products

• 117416-11-2 1-benzyl-6-methoxy-2-piperidinone 
• 1435951-74-8 1-benzyl-6-hydroxy-6-methylpiperidin-2-one 
• 1448179-75-6 1-benzyl-6-(2-oxopropyl)piperidin-2-one 
• 111-29-5 1 ,5-pentanediol 
• 100-46-9 benzylamine 
• 1240792-21-5 methyl 1-benzyl-2,6-dioxopiperidine-3-carboxylate 
• 41267-62-3 1-benzyl-6-phenyl-3,4-dihydropyridin-2(1H)-one 
• 107520-59-2 N-Benzyl-5,6-dihydro-6-phenyl-2(1H)-pyridinone 

Relevant articles and documents

A Unified Strategy for the Synthesis of Difluoromethyl- And Vinylfluoride-Containing Scaffolds

Here, we report a general method for the synthesis of quaternary and tertiary difluoromethylated compounds and their vinylfluoride analogues. The strategy, which relies on a two-step sequence featuring a C-selective electrophilic difluoromethylation and either a palladium-catalyzed decarboxylative protonation or a Krapcho decarboxylation, is practical, scalable, and high yielding. Considering the generality of the method and the attractive properties offered by the difluoromethyl group, this approach provides a valuable tool for late-stage functionalization and drug development.

Highly Enantioselective, Base-Free Synthesis of α-Quaternary Succinimides through Catalytic Asymmetric Allylic Alkylation

The synthesis of diversely substituted five-membered ring succinimide derivatives is reported featuring a direct, base-free, palladium-catalyzed asymmetric allylic alkylation. The method allows a straightforward access to the desired heterocyclic scaffold bearing an all-carbon α-quaternary stereogenic center in high yields and good to excellent enantioselectivities. To further demonstrate the synthetic utility of the method, the allylated products were further converted to various versatile chiral building blocks, including a chiral pyrrolidine and a spirocyclic derivative, using selective transformations.

Synthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex

The first example of base-metal-catalyzed dehydrogenative coupling of diols and amines to form cyclic imides is reported. The reaction is catalyzed by a pincer complex of the earth abundant manganese and forms hydrogen gas as the sole byproduct, making the overall process atom economical and environmentally benign.