3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid

Base Information

Chemical Name:3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid
CAS No.:1361582-95-7
Molecular Formula:C₁₇H₁₇F₃N₂O₄S
Molecular Weight:402.394
Hs Code.:

Synonyms:

Suppliers and Price of 3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid

There total 6 articles about 3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73627-16-4
N-[2-(1H-pyrrol-1-yl)ethyl]acetamide

: 1361582-95-7
3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / water / 24 h / Reflux

2.1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

3.1: trifluoroacetic acid / 16 h / 0 - 20 °C

3.2: pH ~ 7

4.1: hydrogen / palladium on activated charcoal / methanol / 6 h / 20 °C

5.1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 4 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; triethylamine; trifluoroacetic acid; potassium hydroxide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water;

Reference yield:

: 29709-35-1
1-(2-aminoethyl)pyrrole

: 1361582-95-7
3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 - 5 °C / Inert atmosphere

2.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

2.2: pH > 7

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 14 h / 20 °C

4.1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 4 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;

Reference yield:

: 1361582-42-4
ethyl 4-(2-(1H-pyrrol-1-yl)ethylamino)-4-oxobutanoate

: 1361582-95-7
3-[2-[[3-(trifluoromethyl)phenyl]sulfonyl]-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazin-1-yl]propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic acid / 0 - 20 °C / Inert atmosphere

1.2: pH > 7

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 14 h / 20 °C

3.1: triethylamine / dichloromethane / 14 h / 0 - 20 °C

4.1: water; lithium hydroxide monohydrate / tetrahydrofuran; methanol / 4 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; triethylamine; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane;