Technology Process of 3-((6-chloro-2-methyl-1-phenyl-1H-indol-3-yl)thio)benzoic acid
There total 4 articles about 3-((6-chloro-2-methyl-1-phenyl-1H-indol-3-yl)thio)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
copper(l) iodide; 1,10-Phenanthroline; caesium carbonate;
In
N,N-dimethyl-formamide;
at 110 ℃;
for 48h;
Inert atmosphere;
Microwave irradiation;
DOI:10.1021/acs.jmedchem.6b01597
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / 0 °C
1.2: 16 h / 0 - 20 °C
2.1: ethanol / Reflux
3.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; water / acetonitrile / 16 h / 70 °C
4.1: 1,10-Phenanthroline; copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 48 h / 110 °C / Inert atmosphere; Microwave irradiation
With
copper(l) iodide; 1,10-Phenanthroline; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); water; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate;
In
tetrahydrofuran; ethanol; N,N-dimethyl-formamide; acetonitrile;
2.1: |Fischer Indole Synthesis;
DOI:10.1021/acs.jmedchem.6b01597
- Guidance literature:
-
Multi-step reaction with 3 steps
1: ethanol / Reflux
2: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; water / acetonitrile / 16 h / 70 °C
3: 1,10-Phenanthroline; copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 48 h / 110 °C / Inert atmosphere; Microwave irradiation
With
copper(l) iodide; 1,10-Phenanthroline; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); water; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium hydroxide; tri tert-butylphosphoniumtetrafluoroborate;
In
ethanol; N,N-dimethyl-formamide; acetonitrile;
1: |Fischer Indole Synthesis;
DOI:10.1021/acs.jmedchem.6b01597
